Herb & supplement monograph

Grape Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Grape interacts with medications. The heart of this page is the interaction list — every drug Grape is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Grape is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Grape Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Grape drug interaction appears low for most people. None of the listed interactions are rated major, and while many carry a moderate rating, nearly all rest on lab or theoretical findings rather than proven effects in people.

Interactions deserving the most attention

The interaction with the strongest human evidence involves cyclosporine, a transplant medication with a narrow margin for error; a small human study found grape juice can meaningfully reduce how much of the drug the body absorbs. Human data also suggest grape juice may lower levels of certain medications the body clears through a particular liver enzyme. In addition, grape extracts might in theory add to the effects of blood thinners and raise bleeding risk, though this comes from lab research only.

What the rest of the list means

Grape appears on many medication lists mainly because lab and animal studies suggest it could affect enzymes the body uses to process drugs. Those predicted effects have largely not been confirmed in people, and in at least one human study a suspected effect did not occur. A long list here reflects caution, not proof of harm.

Check your medications against Grape

Based on HelloPharmacist’s Grape interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Grape

910 medications have a known interaction with Grape, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
Ado-trastuzumab EmtansineKadcyla
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Read the full Grape + Ado-trastuzumab Emtansine interaction Ado-trastuzumab Emtansine drug page: uses, dosage & side effects
AbciximabReoPro
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Grape + Abciximab interaction
AbemaciclibVerzenio
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Read the full Grape + Abemaciclib interaction Abemaciclib drug page: uses, dosage & side effects
Abiraterone
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Read the full Grape + Abiraterone interaction Abiraterone drug page: uses, dosage & side effects
Abiraterone AcetateYonsa, Zytiga
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Read the full Grape + Abiraterone Acetate interaction Abiraterone Acetate drug page: uses, dosage & side effects
AbrocitinibCibinqo
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Grape + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AcalabrutinibCalquence
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Read the full Grape + Acalabrutinib interaction Acalabrutinib drug page: uses, dosage & side effects
AcenocoumarolSintrom
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Grape + Acenocoumarol interaction
AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.

Read the full Grape + Acetaminophen interaction Acetaminophen drug page: uses, dosage & side effects
Acetaminophen, AspirinGemnisyn
Moderate Cytochrome P450 2e1 (cyp2e1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.

Read the full Grape + Acetaminophen, Aspirin interaction
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Grape + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
Moderate Cytochrome P450 2e1 (cyp2e1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.

Read the full Grape + Acetaminophen, Brompheniramine, Phenylpropanolamine interaction
Acetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.

Read the full Grape + Acetaminophen, Butalbital interaction
Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
Moderate Cytochrome P450 2e1 (cyp2e1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.

Read the full Grape + Acetaminophen, Butalbital, Caffeine interaction Acetaminophen, Butalbital, Caffeine drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Read the full Grape + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Butalbital, CodeineBancap w/ Codeine
Moderate Cytochrome P450 2e1 (cyp2e1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.

Read the full Grape + Acetaminophen, Butalbital, Codeine interaction
Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.

Read the full Grape + Acetaminophen, Butalbital, Codeine Phosphate interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Cytochrome P450 2e1 (cyp2e1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.

Read the full Grape + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.

Read the full Grape + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.

Read the full Grape + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Moderate Cytochrome P450 2e1 (cyp2e1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.

Read the full Grape + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Caffeine, IsomethepteneMigralam
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.

Read the full Grape + Acetaminophen, Caffeine, Isometheptene interaction
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Read the full Grape + Acetaminophen, Caffeine, Pyrilamine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Moderate Cytochrome P450 2e1 (cyp2e1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.

Read the full Grape + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.

Read the full Grape + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Moderate Cytochrome P450 2e1 (cyp2e1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.

Read the full Grape + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Read the full Grape + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.

Read the full Grape + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Moderate Cytochrome P450 2e1 (cyp2e1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.

Read the full Grape + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Read the full Grape + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Grape combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Grape affects

Every type of medication (drug category) Grape is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 9 drug categories Grape interacts with
Anticoagulant/antiplatelet DrugsCyclosporine (neoral, Sandimmune)Cytochrome P450 1a2 (cyp1a2) SubstratesCytochrome P450 2d6 (cyp2d6) SubstratesCytochrome P450 2e1 (cyp2e1) SubstratesCytochrome P450 3a4 (cyp3a4) SubstratesMidazolam (versed)PhenacetinCytochrome P450 2c9 (cyp2c9) Substrates
Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D
Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D
Monograph

Grape: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is healthy and generally safe, the supplement evidence for treating specific conditions is mostly limited or preliminary. Talk with your pharmacist or doctor before starting a grape supplement.

Grape
Scientific name
Vitis vinifera
Family
Vitaceae
Part used
Fruit, skin, seed, and leaves
Common forms
Fresh fruit, juice, wine, capsules, tablets, grape seed extract, and standardized extracts
People commonly use it for
  • Antioxidant support
  • Heart and circulation health
  • Vein problems (such as varicose veins)
  • Eye health
  • General anti-inflammatory support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallLikely safe

Grapes as food are safe for most people, and grape seed extract appears generally well tolerated in studies.

PregnancyLikely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of medicinal amounts during...

Read the full pregnancy detail
BreastfeedingLikely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of medicinal amounts during...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Grape comes from the plant Vitis vinifera, a woody vine grown around the world. Grapes have been cultivated for thousands of years for food, raisins, juice, and wine. They also have a long history of use in traditional medicine.

The fruit, skin, seeds, and leaves all contain natural compounds that people believe may have health benefits. Today, grape products are sold not only as food and drinks but also as dietary supplements, with grape seed extract being one of the most popular forms.

Grape supplements are often standardized to contain a certain amount of polyphenols or proanthocyanidins, which are the compounds thought to be responsible for many of the proposed effects.

How it works

Grapes contain a variety of natural compounds, including resveratrol, flavonoids, and proanthocyanidins (a type of polyphenol especially concentrated in the seeds and skin).

These compounds act as antioxidants, meaning they may help protect cells from a type of damage caused by unstable molecules called free radicals. They are also thought to have anti-inflammatory effects and may support healthy blood vessels and circulation.

It is important to know that much of what we understand about how these compounds work comes from laboratory and animal research. How well they work in the human body, and at what doses, is still being studied.

Effectiveness

Does Grape work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 35 uses evaluated
1 Possibly effective 5 Leans ineffective 29 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Chronic venous insufficiency (CVI)
Rating & evidence shown verbatim from Natural Medicines

Oral grape leaf extract might improve CVI symptoms. It is unknown if other grape products are beneficial for CVI.

Possibly Ineffective Allergic rhinitis (hay fever)
Rating & evidence shown verbatim from Natural Medicines

Oral grape seed extract does not seem to improve hay fever symptoms.

Possibly Ineffective Chemotherapy-induced nausea and vomiting (CINV)
Rating & evidence shown verbatim from Natural Medicines

Drinking grape juice does not seem to improve CINV.

Possibly Ineffective Lower urinary tract symptoms (LUTS)
Rating & evidence shown verbatim from Natural Medicines

Drinking grape juice does not seem to improve LUTS.

Possibly Ineffective Mastalgia
Rating & evidence shown verbatim from Natural Medicines

Oral grape seed extract does not seem to improve mastalgia symptoms.

Possibly Ineffective Obesity
Rating & evidence shown verbatim from Natural Medicines

Oral grape products do not seem to improve weight loss.

Also studied for 29 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Age-related macular degeneration (AMD)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral grape seed for AMD, there is insufficient reliable information about the clinical effects of grape for this condition.

Insufficient Reliable Evidence To Rate Aging skin
Rating & evidence shown verbatim from Natural Medicines

Oral grape skin extract has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Atherosclerosis
Rating & evidence shown verbatim from Natural Medicines

Oral grape seed extract has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Athletic performance
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral grape products are beneficial for athletic performance.

Insufficient Reliable Evidence To Rate Atopic dermatitis (eczema)
Rating & evidence shown verbatim from Natural Medicines

Topical grape products have only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Attention deficit-hyperactivity disorder (ADHD)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral grape seed for ADHD, there is insufficient reliable information about the clinical effects of grape for this condition.

Insufficient Reliable Evidence To Rate Canker sores
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral grape seed for canker sores, there is insufficient reliable information about the clinical effects of grape for this condition.

Insufficient Reliable Evidence To Rate Cardiovascular disease (CVD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral grape products are beneficial for reducing CVD risk.

Insufficient Reliable Evidence To Rate Cognitive function
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral grape products improve cognitive function.

Insufficient Reliable Evidence To Rate Cognitive impairment
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that oral grape products may not slow cognitive decline in older patients with cognitive impairment.

Insufficient Reliable Evidence To Rate Colorectal cancer
Rating & evidence shown verbatim from Natural Medicines

Oral grape seed extract is has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Constipation
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral grape products for constipation, there is insufficient reliable information about the clinical effects of grape for this condition.

Insufficient Reliable Evidence To Rate Dental caries
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical grape seed for dental caries, there is insufficient reliable information about the clinical effects of grape for this purpose.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Oral grape extract has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Diabetic retinopathy
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral grape seed extract is beneficial in patients with diabetic retinopathy.

Insufficient Reliable Evidence To Rate Erectile Dysfunction (ED)
Rating & evidence shown verbatim from Natural Medicines

Oral grape extract has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Hemorrhoids
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral grape seed for hemorrhoids, there is insufficient reliable information about the clinical effects of grape for this purpose.

Insufficient Reliable Evidence To Rate Hypercholesterolemia
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that oral grape products reduce cholesterol levels by a small amount.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Some research suggests that oral grape products may modestly lower blood pressure; however, results are inconsistent.

Insufficient Reliable Evidence To Rate Melasma
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral grape seed extract is beneficial in patients with melasma.

Insufficient Reliable Evidence To Rate Menopausal symptoms
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral grape seed extract is beneficial in patients with menopausal symptoms.

Insufficient Reliable Evidence To Rate Metabolic syndrome
Rating & evidence shown verbatim from Natural Medicines

Small studies suggest that various oral grape products might improve lipid levels and blood pressure in patients with metabolic syndrome.

Insufficient Reliable Evidence To Rate Minor bleeding
Rating & evidence shown verbatim from Natural Medicines

Topical grape vine has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Muscle soreness
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral grape products improve muscle soreness.

Insufficient Reliable Evidence To Rate Night vision
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral grape seed extract for improving night vision, there is insufficient reliable information about the clinical effects of grape for purpose.

Insufficient Reliable Evidence To Rate Nonalcoholic fatty liver disease (NAFLD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral grape seed extract reverses fatty liver in patients with NAFLD.

Insufficient Reliable Evidence To Rate Ocular stress
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral grape seed extract for ocular stress, there is insufficient reliable information about the clinical effects of grape for this purpose.

Insufficient Reliable Evidence To Rate Premenstrual syndrome (PMS)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral grape seed extract for PMS, there is insufficient reliable information about the clinical effects of grape for this condition.

Insufficient Reliable Evidence To Rate Wound healing
Rating & evidence shown verbatim from Natural Medicines

Limited research suggests that topical grape seed extract might improve wound healing.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Eating grapes, raisins, and drinking grape juice is safe for most people as part of a normal diet. Grape seed extract supplements also appear to be generally well tolerated when used short term.

Who should be cautious: People with bleeding disorders, those taking blood-thinning medicines, and anyone scheduled for surgery should talk to a healthcare provider before using concentrated grape supplements, since some grape compounds may affect blood clotting.

Pregnancy: Grapes as food are fine, but concentrated supplements have not been well studied, so it is best to avoid them. Wine and other alcoholic grape products should be avoided entirely during pregnancy.

Breastfeeding: Grapes as food are fine, but there is not enough safety information on grape seed extract or other concentrated products, so caution is advised.

Always check with your pharmacist or doctor before starting any new supplement, especially if you have a health condition or take other medicines.

Side effects

Grapes and grape products are usually well tolerated. When side effects happen, they are typically mild.

Possible side effects of grape seed extract may include headache, dizziness, upset stomach, or nausea. Some people may have an allergic reaction to grapes or grape products, which can rarely be serious.

Stop using the product and seek medical care if you notice signs of an allergic reaction such as rash, itching, swelling, or trouble breathing.

Grape: Reported Adverse Effects

Documented safety reports on Grape from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, the whole fruit, as well as the seed, fruit, and leaf extracts, seem to be well tolerated. Topically, grape seed extracts seem to be well tolerated.

Most Common Adverse Effects:

Orally: Abdominal pain, diarrhea, dry mouth, dyspepsia, headache, joint pain, and nausea.

Serious Adverse Effects (Rare):

Orally: Anaphylaxis to grape skin has been reported.

Reports by condition
Allergic rhinitis (hay fever) Pulmonary/Respiratory

Orally, nasopharyngitis and oropharyngeal pain have been reported with use of a specific grape leaf extract AS195 (Antistax, Boehringer Ingelheim Pharma GmbH & Co. KG). Sore throat, cough, allergic rhinitis, and nasopharyngitis have been reported with use of grape seed extract, but these effects occur at rates similar to placebo. One case report describes a 16-year-old female who developed increased levels of immunoglobulin E (IgE) following skin-prick exposure to grape vine pollen, as well as positive test responses following bronchial and conjunctival provocation. Reduced forced vital capacity has been described in California grape workers. Occupational eosinophilic lung was diagnosed in a grape grower with a history of asthma. Respiratory exposure to sulfites in grape was implicated as the cause of the adverse reaction.

  1. Rabe, E., Stucker, M., Esperester, A., Schafer, E., and Ottillinger, B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur.J Vasc.Endovasc.
  2. Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8..
  3. Ras RT, Zock PL, Zebregs YE, et al. Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension. Br J Nutr 2013;110(12):2234-41.
  4. Brito, FF., Martinez, A., Palacios, R., Mur, P., Gomez, E., Galindo, P. A., Borja, J., and Martinez, J. Rhinoconjunctivitis and asthma caused by vine pollen: a case report. J Allergy Clin Immunol 1999;103(2 Pt 1):262-266.
  5. Samet, J. M. and Coultas, D. B. Reduced forced vital capacity in California grape workers. What does it mean? Am Rev.Respir.Dis 1992;145(2 Pt 1):255-256.
  6. Gamsky, T. E., McCurdy, S. A., Samuels, S. J., and Schenker, M. B. Reduced FVC among California grape workers. Am Rev.Respir.Dis 1992;145(2 Pt 1):257-262.
  7. Marguerie, C. and Drouet, M. [Occupational eosinophilic lung in a grape grower: role of sulfites]. Allerg.Immunol.(Paris) 1995;27(5):163-167.
Back pain Musculoskeletal

Orally, musculoskeletal disorders, including back pain, have been reported with use of a specific grape leaf extract AS195 (Antistax, Boehringer Ingelheim Pharma GmbH & Co. KG). Joint pain and lumbago have been reported with use of grape seed extract, but these effects occur at rates similar to placebo.

  1. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
  2. Rabe, E., Stucker, M., Esperester, A., Schafer, E., and Ottillinger, B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur.J Vasc.Endovasc.
  3. Ras RT, Zock PL, Zebregs YE, et al. Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension. Br J Nutr 2013;110(12):2234-41.
Cluster headache Neurologic/CNS

Orally, headache has been reported with use of grape seed extract, but this effect occurs at rates similar to placebo. A specific grape leaf extract AS195 (Antistax, Boehringer Ingelheim Pharma GmbH & Co. KG) has reportedly caused dizziness, tiredness, headache, and sleep problems. As a class, nervous system adverse effects have been reported with use of a specific grape seed extract (Entelon, Hanlim Pharm). However, the specific types of adverse neurologic effects were not described.

  1. Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8..
  2. Ras RT, Zock PL, Zebregs YE, et al. Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension. Br J Nutr 2013;110(12):2234-41.
  3. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
  4. Rabe, E., Stucker, M., Esperester, A., Schafer, E., and Ottillinger, B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur.J Vasc.Endovasc.
  5. Moon SW, Shin YU, Cho H, Bae SH, Kim HK; and for the Mogen Study Group. Effect of grape seed proanthocyanidin extract on hard exudates in patients with non-proliferative diabetic retinopathy. Medicine (Baltimore) 2019;98(21):e15515.
Constipation Gastrointestinal

Orally, abdominal pain and nausea have been reported with use of grape seed extract, but these effects typically occur at rates similar to placebo. In a case report of a 57-year-old man, intermittent nausea, vomiting, and diarrhea occurred over a 10-day period and improved once grape seed extract was stopped. Gastrointestinal adverse effects have also been reported with use of a different grape seed extract (Entelon, Hanlim Pharm). However, the specific types of gastrointestinal effects were not described. A specific grape leaf extract AS195 (Antistax, Boehringer Ingelheim Pharma GmbH & Co. KG) has reportedly caused flatulence, mild constipation, gastrointestinal discomfort, diarrhea, dyspepsia, dry mouth, and retching. Diarrhea, gastrointestinal distress, indigestion, and aversion to taste have been reported with use of Concord grape juice. Loose stools have been reported in a clinical trial of grape pomace. Bowel obstruction caused by intact grapes and grape seeds has been described in case reports. Excessive consumption of grapes, dried grapes, raisins, or sultanas might cause diarrhea due to laxative effects.

  1. Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8..
  2. Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34..
  3. Berry AC, Nakshabendi R, Abidali H, et al. Adverse effects of grape seed extract supplement: A clinical case and long-term follow-up. J Diet Suppl. 2016;13(2):232-5.
  4. Moon SW, Shin YU, Cho H, Bae SH, Kim HK; and for the Mogen Study Group. Effect of grape seed proanthocyanidin extract on hard exudates in patients with non-proliferative diabetic retinopathy. Medicine (Baltimore) 2019;98(21):e15515.
  5. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
  6. Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschun
  7. Rabe, E., Stucker, M., Esperester, A., Schafer, E., and Ottillinger, B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur.J Vasc.Endovasc.
  8. O'Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374.
  9. Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., and Joseph, J. A. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010;103(5):730-734.
  10. Ingersoll, G. L., Wasilewski, A., Haller, M., Pandya, K., Bennett, J., He, H., Hoffmire, C., and Berry, C. Effect of concord grape juice on chemotherapy-induced nausea and vomiting: results of a pilot study. Oncol.Nurs.Forum 2010;37(2):213-221.
  11. Hollis, J. H., Houchins, J. A., Blumberg, J. B., and Mattes, R. D. Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults. J Am Coll.Nutr. 2009;28(5):574-582.
  12. Dohadwala, M. M., Hamburg, N. M., Holbrook, M., Kim, B. H., Duess, M. A., Levit, A., Titas, M., Chung, W. B., Vincent, F. B., Caiano, T. L., Frame, A. A., Keaney, J. F., Jr., and Vita, J. A. Effects of Concord grape juice on ambulatory blood pressure in
  13. Martínez-Maqueda D, Zapatera B, Gallego-Narbón A, Vaquero MP, Saura-Calixto F, Pérez-Jiménez J. A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome mark
  14. Trotta, M., Cesaretti, M., Conzi, R., Derchi, L. E., and Borgonovo, G. Elderly male with mesogastric pain. Small bowel obstruction caused by an intact fresh grape. Ann.Emerg.Med 2011;58(4):e1-e2.
  15. Faircloth, D. E. and Robison, W. J. Obstruction of the sigmoid colon by grape seeds. JAMA 11-27-1981;246(21):2430.
  16. Cox, J. and Grigg, M. Small bowel obstruction by an intact grape. J Am Geriatr.Soc 1986;34(7):550.
  17. Chevallier A. The Encyclopedia of Medicinal Plants. London, UK: Dorling Kindersley, Ltd., 1996.
Critical illness (trauma) Hematologic

Orally, one case of leg hematoma following a minor trauma was reported in a person using grape leaf extract. Also, one case of bruising was reported in a person drinking Concord grape juice daily for 2 weeks.

  1. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
  2. O'Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374.
Dermatitis Dermatologic

Orally, mild hair thinning has been reported in a patient taking a specific grape leaf extract AS195 (Antistax, Boehringer Ingelheim Pharma GmbH & Co. KG). Urticaria (hives) has also been reported with this same extract. Cases of contact dermatitis have been reported in grape workers, including those working in California vineyards.

  1. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
  2. Rabe, E., Stucker, M., Esperester, A., Schafer, E., and Ottillinger, B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur.J Vasc.Endovasc.
  3. McCurdy, S. A., Wiggins, P., Schenker, M. B., Munn, S., Shaieb, A. M., Weinbaum, Z., Goldsmith, D., McGillis, S. T., Berman, B., and Samuels, S. Assessing dermatitis in epidemiologic studies: occupational skin disease among California grape and tomato ha
  4. Winter, C. K. and Kurtz, P. H. Factors influencing grape worker susceptibility to skin rashes. Bull.Environ.Contam Toxicol. 1985;35(3):418-426.
  5. Yamasaki, R., Dekio, S., and Jidoi, J. Contact dermatitis from grape bud. Contact Dermatitis 1985;12(4):226-227.
Urticaria Immunologic

Orally, there is one report of an anaphylactic reaction to oral grape skin extract, which included urticaria and angioedema.

  1. Vaswani SK, Hamilton RG, Carey RN, et al. Anaphylaxis recurrent urticaria and angioedema from grape hypersensitivity. J Allergy Clin Immunol 1998;101:S31.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no single official or proven dose for grape supplements. The right amount can depend on the specific product, the form (such as grape seed extract), and how it is standardized.

Because products vary widely in strength, the best approach is to follow the directions on the product label and not exceed the recommended amount. Look for products that clearly list their polyphenol or proanthocyanidin content.

Check with your pharmacist or doctor before starting, especially if you take other medicines or have a health condition. They can help you decide whether a grape supplement is appropriate for you.

Pregnancy & Breastfeeding

Grape & Pregnancy

Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of medicinal amounts during pregnancy and breast-feeding; avoid using in amounts greater than what is commonly found in foods.

Grape & Breastfeeding

Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of medicinal amounts during pregnancy and breast-feeding; avoid using in amounts greater than what is commonly found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 34 references that drive our Grape monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
  2. Xiao Dong S, Zhi Ping Z, Zhong Xiao W, et al. Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects. Br J Clin Pharmacol 1999;48:638-40. PubMed
  3. Vaswani SK, Hamilton RG, Carey RN, et al. Anaphylaxis recurrent urticaria and angioedema from grape hypersensitivity. J Allergy Clin Immunol 1998;101:S31.
  4. Chevallier A. The Encyclopedia of Medicinal Plants. London, UK: Dorling Kindersley, Ltd., 1996.
  5. Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8.. PubMed
  6. Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
  7. Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. PubMed
  8. Ray, S. D., Parikh, H., Hickey, E., Bagchi, M., and Bagchi, D. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome 4502E1-dependent aniline hydroxylation. Mol Cell B PubMed
  9. O'Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374.
  10. Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschun PubMed
  11. Nishikawa, M., Ariyoshi, N., Kotani, A., Ishii, I., Nakamura, H., Nakasa, H., Ida, M., Nakamura, H., Kimura, N., Kimura, M., Hasegawa, A., Kusu, F., Ohmori, S., Nakazawa, K., and Kitada, M. Effects of continuous ingestion of green tea or grape seed extra
  12. de Lange, D. W., Scholman, W. L., Kraaijenhagen, R. J., Akkerman, J. W., and van de Wiel, A. Alcohol and polyphenolic grape extract inhibit platelet adhesion in flowing blood. Eur.J Clin.Invest 2004;34(12):818-824. PubMed
  13. Samet, J. M. and Coultas, D. B. Reduced forced vital capacity in California grape workers. What does it mean? Am Rev.Respir.Dis 1992;145(2 Pt 1):255-256. PubMed
  14. Gamsky, T. E., McCurdy, S. A., Samuels, S. J., and Schenker, M. B. Reduced FVC among California grape workers. Am Rev.Respir.Dis 1992;145(2 Pt 1):257-262. PubMed
  15. de Lange, D. W., Verhoef, S., Gorter, G., Kraaijenhagen, R. J., van de Wiel, A., and Akkerman, J. W. Polyphenolic grape extract inhibits platelet activation through PECAM-1: an explanation for the French paradox. Alcohol Clin.Exp.Res 2007;31(8):1308-1314 PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Grape

1,296 brands in our database make a supplement containing Grape.

Product directory

Supplement products with Grape

8,826 products in our database contain Grape. Open any to see its full ingredient list and every drug interaction we check.

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Pharmacist Counseling Corner

Grape: Common Questions

What is Grape used for, and does it work?
People use Grape for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Grape for Chronic venous insufficiency (CVI). For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Grape interact with prescription medications?
Yes. We list 910 medications with a known interaction with Grape. Use the checker above to see how Grape interacts with a specific drug.
How are Grape interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Grape with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Grape interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Grape seed extract used for?
People commonly take Grape seed extract for antioxidant support, heart and circulation health, and vein problems. The evidence for most of these uses is limited or preliminary, so it should not replace proven treatments.
Is it better to eat Grapes or take a supplement?
Eating Grapes provides fiber, water, and a mix of natural compounds as part of a healthy diet. Supplements offer a more concentrated dose of certain compounds, but they are not a substitute for a balanced diet and have less proven benefit.
Are Grape supplements safe?
Grapes as food are safe for most people, and Grape seed extract is generally well tolerated short term. People with bleeding disorders, those on blood thinners, and anyone who is pregnant or breastfeeding should check with a healthcare provider first.
Does Grape seed extract contain alcohol?
No. Grape seed extract is made from the seeds and does not contain alcohol. Wine, however, does contain alcohol and should be avoided during pregnancy and limited in general.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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