Herb & supplement monograph

Dhea Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Dhea interacts with medications. The heart of this page is the interaction list — every drug Dhea is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Dhea is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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On this page

Dhea Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Dhea drug interaction appears low for most people, though a few specific medicines deserve real caution. None of the hundreds of listed interactions are rated major, and nearly all rest on theoretical or preliminary evidence rather than proven harm in people.

Interactions deserving the most attention

The clearest concern is with anti-estrogen cancer treatments such as tamoxifen, aromatase inhibitors, and fulvestrant, because DHEA acts like estrogen in the body and may work against these drugs. The best-documented interaction is with triazolam, a sleep medicine, since a human study showed DHEA raised its blood levels. There is also a theoretical bleeding concern with blood thinners, based on research showing DHEA may affect how platelets clump, and a single case report of a manic episode when DHEA was combined with an antidepressant.

What the rest of the list means

The long list of interacting medications looks daunting, but most entries come from one theoretical mechanism: DHEA may slow an enzyme the body uses to clear many common drugs. For most of these, the effect has only been seen in early research, and its real-world significance is unknown. A long list here signals caution, not proven harm.

Check your medications against Dhea

Based on HelloPharmacist’s Dhea interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Dhea

776 medications have a known interaction with Dhea, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
Ado-trastuzumab EmtansineKadcyla
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Ado-trastuzumab Emtansine interaction Ado-trastuzumab Emtansine drug page: uses, dosage & side effects
AbciximabReoPro
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Dhea + Abciximab interaction
AbemaciclibVerzenio
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Abemaciclib interaction Abemaciclib drug page: uses, dosage & side effects
Abiraterone
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Abiraterone interaction Abiraterone drug page: uses, dosage & side effects
Abiraterone AcetateYonsa, Zytiga
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Abiraterone Acetate interaction Abiraterone Acetate drug page: uses, dosage & side effects
AbrocitinibCibinqo
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Dhea + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AcalabrutinibCalquence
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acalabrutinib interaction Acalabrutinib drug page: uses, dosage & side effects
AcenocoumarolSintrom
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Dhea + Acenocoumarol interaction
Acetaminophen, AspirinGemnisyn
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Dhea + Acetaminophen, Aspirin interaction
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Dhea + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Butalbital, Caffeine interaction Acetaminophen, Butalbital, Caffeine drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Caffeine, IsomethepteneMigralam
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Caffeine, Isometheptene interaction
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Caffeine, Pyrilamine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Chlorpheniramine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full Dhea + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Dhea combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Dhea affects

Every type of medication (drug category) Dhea is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 10 drug categories Dhea interacts with
Anticoagulant/antiplatelet DrugsAntidepressant DrugsAromatase InhibitorsCytochrome P450 3a4 (cyp3a4) SubstratesFulvestrant (faslodex)Tamoxifen (nolvadex)Triazolam (halcion)Tuberculosis VaccineEstrogensTestosterone
Anticoagulant/Antiplatelet Drugs

Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Human and laboratory research show that DHEA and DHEA-S can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, DHEA might increase the risk of psychiatric adverse events when used with antidepressants.
In a human case report, the use of a selective serotonin reuptake inhibitor (SSRI) with DHEA caused a manic episode. Concern for this interaction may be greater in younger individuals with higher baseline DHEA levels.

Likelihood Possible Evidence D
Aromatase Inhibitors

Theoretically, DHEA might interfere with the clinical effects of aromatase inhibitors.
DHEA is a potent estrogen agonist, which may antagonize the anti-estrogen activity of aromatase inhibitors.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Some preliminary evidence shows that DHEA may inhibit CYP3A4; however, the clinical significance of this potential interaction is not known.

Likelihood Possible Evidence D
Fulvestrant (Faslodex)

Theoretically, DHEA might interfere with the anti-estrogen effects of fulvestrant.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist action of fulvestrant in estrogen-receptor positive cancer cells.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, DHEA might interfere with the anti-estrogen effects of tamoxifen.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist activity of tamoxifen in estrogen-receptor positive cancer cells.

Likelihood Possible Evidence D
Triazolam (Halcion)

DHEA can increase blood levels of triazolam.
Administration of DHEA 200 mg daily for two weeks was shown to inhibit the cytochrome P450 3A4 (CYP3A4) metabolism of triazolam. This inhibition appears to be due to DHEA-S, rather than DHEA.

Likelihood Probable Evidence D
Tuberculosis Vaccine

DHEA might reduce the effectiveness of the tuberculosis vaccine.
Animal research shows that high doses of DHEA can reduce the efficacy of the Bacillus Calmette-Guérin (BCG) tuberculosis vaccine.

Likelihood Possible Evidence D
Estrogens

Theoretically, DHEA might increase the effects and adverse effects of estrogen therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. Also, in clinical research, estrogen-progestin oral contraceptives and conjugated estrogens reduce blood levels of DHEA and DHEA-S. The clinical significance of these findings is unclear.

Likelihood Possible Evidence D
Testosterone

Theoretically, DHEA might increase the effects and side effects of testosterone therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. The clinical significance of these findings is unclear.

Likelihood Possible Evidence D
Monograph

Dhea: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits. The evidence is mixed and limited for most uses, and because it acts as a hormone it can cause real side effects. Talk to a pharmacist or doctor before using it, especially if you have a hormone-sensitive condition.

Dhea
Part used
DHEA is a hormone made by the body; supplements are made synthetically, often from compounds found in wild yam or soy
Common forms
Capsules, tablets, sublingual drops, topical creams, vaginal inserts (prasterone)
People commonly use it for
  • Anti-aging and low DHEA levels
  • Mood and depression
  • Vaginal dryness and sexual health
  • Fertility support
  • Muscle mass and athletic performance
  • Adrenal insufficiency

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

As a hormone, DHEA can cause hormonal side effects and should be used only with medical guidance.

PregnancyPossibly Unsafe

When used orally. DHEA can cause higher than normal androgen levels, which might adversely affect pregnancy or a nursing infant.

Read the full pregnancy detail
BreastfeedingPossibly Unsafe

When used orally. DHEA can cause higher than normal androgen levels, which might adversely affect pregnancy or a nursing infant.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

DHEA (dehydroepiandrosterone) is a hormone made naturally by your adrenal glands, which sit on top of your kidneys. It is one of the most plentiful steroid hormones in the body and serves as a building block that the body can turn into other hormones, including testosterone and estrogen.

DHEA levels are highest in young adulthood and slowly drop as people get older. Because of this natural decline, DHEA has become a popular over-the-counter supplement marketed for anti-aging, energy, mood, and sexual health.

Supplement DHEA is made in a laboratory, often starting from compounds found in wild yam or soy. Importantly, your body cannot make DHEA from eating wild yam itself, so a wild yam product is not the same as a DHEA supplement.

How it works

DHEA is a precursor hormone, meaning the body can convert it into other hormones, mainly testosterone and estrogen. By raising the supply of these sex hormones, DHEA may influence mood, sex drive, bone, muscle, and tissue health.

Because hormone levels fall with age, the idea behind supplementing is to restore some of what is lost. However, more hormone is not always better, and the body's hormone systems are complex.

Much of what we understand about DHEA's effects comes from laboratory and animal studies, and the way it works in the human body is not fully understood. Effects can vary a lot between men and women and between individuals.

Effectiveness

Does Dhea work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 37 uses evaluated
1 Likely effective 3 Possibly effective 5 Leans ineffective 28 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Likely Effective Vaginal atrophy
Rating & evidence shown verbatim from Natural Medicines

Intravaginal DHEA can reduce pain during intercourse and improve vaginal health in patients with this condition.

Possibly Effective Aging skin
Rating & evidence shown verbatim from Natural Medicines

Oral and topical DHEA have been evaluated for treating aging skin, with promising results.

Possibly Effective Depression
Rating & evidence shown verbatim from Natural Medicines

Oral DHEA 30-500 mg daily for up to 8 weeks seems to improve symptoms of depression and dysthymia in patients with depression.

Possibly Effective Infertility
Rating & evidence shown verbatim from Natural Medicines

Oral DHEA appears to improve fertility outcomes, including pregnancy and live birth rates, in females undergoing assisted reproduction. However, it is unclear if oral DHEA can reduce the risk for miscarriage after in vitro fertilization (IVF) or intra-cytoplasmic sperm injection (ICSI).

Possibly Ineffective Aging
Rating & evidence shown verbatim from Natural Medicines

Oral DHEA, taken for up to 2 years, does not appear to improve bone health, quality of life, or sexual function in older adults.

Possibly Ineffective Muscle strength
Rating & evidence shown verbatim from Natural Medicines

Oral DHEA does not seem to improve muscle strength in adults.

Possibly Ineffective Physical performance
Rating & evidence shown verbatim from Natural Medicines

Oral DHEA does not seem to improve physical performance in elderly patients.

Likely Ineffective Cognitive function
Rating & evidence shown verbatim from Natural Medicines

Oral DHEA does not improve cognitive function or prevent cognitive decline in most populations.

Likely Ineffective Sjogren syndrome
Rating & evidence shown verbatim from Natural Medicines

Oral DHEA does not appear to improve symptoms with this condition.

Also studied for 28 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Addison disease
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial in patients with this condition.

Insufficient Reliable Evidence To Rate Adrenal insufficiency
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial in patients with primary or secondary adrenal insufficiency.

Insufficient Reliable Evidence To Rate Athletic performance
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA can improve sprint performance.

Insufficient Reliable Evidence To Rate Cardiovascular disease (CVD)
Rating & evidence shown verbatim from Natural Medicines

Observational research has found that low DHEA levels are linked to a greater risk for CVD, but it is unclear if supplementation with oral DHEA is beneficial.

Insufficient Reliable Evidence To Rate Cervical dysplasia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if intravaginal DHEA is beneficial in patients with cervical dysplasia.

Insufficient Reliable Evidence To Rate Chronic fatigue syndrome (CFS)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial in patients with CFS.

Insufficient Reliable Evidence To Rate Chronic obstructive pulmonary disease (COPD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial in patients with COPD.

Insufficient Reliable Evidence To Rate Cocaine dependence
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial for reducing cocaine cravings.

Insufficient Reliable Evidence To Rate Crohn disease
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial for inducing Crohn disease remission.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral DHEA for diabetes, there is insufficient reliable information available about the clinical effects of DHEA for this purpose.

Insufficient Reliable Evidence To Rate Erectile dysfunction (ED)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial in patients with ED.

Insufficient Reliable Evidence To Rate Exercise-induced muscle damage
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial for reducing muscle damage from exercise.

Insufficient Reliable Evidence To Rate Fibromyalgia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial for improving fibromyalgia symptoms.

Insufficient Reliable Evidence To Rate HIV/AIDS
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that oral DHEA may improve mental health and quality of life in patients with HIV/AIDS, but DHEA does not seem to improve CD4 counts or body composition.

Insufficient Reliable Evidence To Rate Menopausal symptoms
Rating & evidence shown verbatim from Natural Medicines

Oral DHEA might reduce hot flashes and intravaginal DHEA might improve vaginal atrophy and sexual activity; however, oral DHEA does not seem to improve psychological symptoms associated with menopause.

Insufficient Reliable Evidence To Rate Metabolic syndrome
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial for reducing risk for metabolic syndrome.

Insufficient Reliable Evidence To Rate Muscular dystrophy
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial in patients with myotonic dystrophy type I.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial for reducing body weight in patients who are obese or overweight.

Insufficient Reliable Evidence To Rate Opioid withdrawal
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial in patients with heroin withdrawal.

Insufficient Reliable Evidence To Rate Osteoporosis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial in patients with osteoporosis; any benefit may depend on individual patient characteristics.

Insufficient Reliable Evidence To Rate Parkinson disease
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral DHEA for Parkinson disease, there is insufficient reliable information available about the clinical effects of DHEA for this purpose.

Insufficient Reliable Evidence To Rate Partial androgen deficiency
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial for symptom improvement in patients with this condition.

Insufficient Reliable Evidence To Rate Parturition
Rating & evidence shown verbatim from Natural Medicines

Intravenous DHEA before the onset of labor may shorten the time to labor onset and shorten labor duration.

Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial in patients with RA.

Insufficient Reliable Evidence To Rate Schizophrenia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial in patients with schizophrenia.

Insufficient Reliable Evidence To Rate Sexual dysfunction
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral or intravaginal DHEA is beneficial for improving sexual dysfunction in males or females.

Insufficient Reliable Evidence To Rate Systemic lupus erythematosus (SLE)
Rating & evidence shown verbatim from Natural Medicines

Most small clinical studies suggest that oral DHEA may modestly improve symptoms in patients with SLE, but some conflicting research exists.

Insufficient Reliable Evidence To Rate Ulcerative colitis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral DHEA is beneficial for inducing ulcerative colitis remission.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Because DHEA acts as a hormone, it should be treated with care. People with hormone-sensitive conditions — such as breast, ovarian, uterine, or prostate cancers — should generally avoid it, since DHEA can raise estrogen or testosterone levels.

People with liver disease, heart conditions, mood disorders, or polycystic ovary syndrome (PCOS) should be cautious and speak with a healthcare provider first. DHEA is banned by many sports organizations, so athletes should avoid it.

Pregnancy and breastfeeding: DHEA changes hormone levels and is considered unsafe during pregnancy. There is not enough information about its safety while breastfeeding, so it should be avoided then too.

Always talk to a pharmacist or doctor before starting DHEA, and remember that supplements are not as tightly regulated as prescription drugs, so quality and strength can vary between products.

Side effects

Common side effects are often related to higher hormone levels and can include oily skin, acne, and hair loss or unwanted hair growth. Some people report stomach upset, high blood pressure, or trouble sleeping.

In women, DHEA can cause more masculine effects such as a deeper voice, facial hair, or changes in menstrual periods. In men, it may cause breast tenderness or enlargement. It can also affect mood and may worsen certain psychiatric conditions.

Because it influences hormones, long-term or high-dose use raises concerns about effects on hormone-sensitive tissues. Stop use and seek medical advice if you notice troubling changes.

Dhea: Reported Adverse Effects

Documented safety reports on Dhea from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally and topically, DHEA seems to be well tolerated when used in typical doses, short-term. However, there is some concern that long-term oral use of DHEA may be linked to a greater risk for cancer.

Most Common Adverse Effects:

Orally: Acne, headache, insomnia, mood changes, and nausea. In females, masculinization symptoms including deepening of the voice, increased size of genitals, irregular menses, oily skin, reduced breast size, and unnatural hair growth. In males, aggression, breast tenderness or enlargement (gynecomastia), urinary urgency, and testicular wasting.

Serious Adverse Effects (Rare):

Orally: Possible increased risk for cardiovascular events and various types of cancer.

Reports by condition
Acne Dermatologic

Acne has been the most commonly reported adverse effect in human research, particularly in females. However, it is generally mild and may be treated by reducing the dose. Incidences of contact dermatitis, acneiform dermatitis, greasy hair and skin, keratosis, skin rash, erythema, scalp itching, and skin spots have also been reported. Increased hair growth and hirsutism have been noted in several clinical trials, including the development of mild mustache in females. Increased perspiration and odor have also been reported in human research.

  1. Van Vollenhoven RF, Morabito LM, Engleman EG, et al. Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months. J Rheumatol 1998;25:285-9.
  2. Van Vollenhoven RF, Engleman EG, McGurie JL. Dehydroepiandrosterone in Systemic Lupus Erythematosus. Arth Rheum 1995;38:1826-31.
  3. Labrie F, Diamond P, Cusan L, et al. Effect of 12 month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women. J Clin Endocrinol Metab 1997;82:3498-505.
  4. Hunt PJ, Gurnell EM, Huppert FA, et al. Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial. J Clin Endocrinol Metab 2000;85:4650-6..
  5. Himmel PB, Seligman TM. A Pilot Study Employing Dehydroepiandrosterone (DHEA) in the Treatment of Chronic Fatigue Syndrome. [Abstract]. J Clin Rheumatol 1999:5:56-9.
  6. Petri MA, Mease PJ, Merrill JT, et al. Effects of prasterone on disease activity and symptoms in women with active systemic lupus erythematosus. Arthritis Rheum 2004;50:2858-68.
  7. Petri MA, Lahita RG, Van Vollenhoven RF, et al. Effects of prasterone on corticosteroid requirements of women with systemic lupus erythematosus: a double-blind, randomized, placebo-controlled trial. Arthritis Rheum 2002;46:1820-9.
  8. Nordmark, G., Bengtsson, C., Larsson, A., Karlsson, F. A., Sturfelt, G., Ronnblom, L. Effects of dehydroepiandrosterone supplement on health-related quality of life in glucocorticoid treated female patients with systemic lupus erythematosus. Autoimmunity
  9. McHenry, C. M., Bell, P. M., Hunter, S. J., Thompson, C. J., Courtney, C. H., Ennis, C. N., Sheridan, B., McCance, D. R., Mullan, K. R., Atkinson, A. B. Effects of dehydroepiandrosterone sulphate (DHEAS) replacement on insulin action and quality of life i
  10. Forsblad-d'Elia, H., Carlsten, H., Labrie, F., Konttinen, Y. T., Ohlsson, C. Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentration
  11. Finckh, A., Berner, I. C., Aubry-Rozier, B., So, A. K. A randomized controlled trial of dehydroepiandrosterone in postmenopausal women with fibromyalgia. J Rheumatol 2005;32(7):1336-40.
  12. Gebre-Medhin, G., Husebye, E. S., Mallmin, H., Helstrom, L., Berne, C., Karlsson, F. A., Kampe, O. Oral dehydroepiandrosterone (DHEA) replacement therapy in women with Addison's disease. Clin Endocrinol (Oxf) 2000;52(6):775-80.
  13. Lovas, K., Gebre-Medhin, G., Trovik, T. S., Fougner, K. J., Uhlving, S., Nedrebo, B. G., Myking, O. L., Kampe, O., Husebye, E. S. Replacement of dehydroepiandrosterone in adrenal failure: no benefit for subjective health status and sexuality in a 9-month,
  14. Pillemer, S. R., Brennan, M. T., Sankar, V., Leakan, R. A., Smith, J. A., Grisius, M., Ligier, S., Radfar, L., Kok, M. R., Kingman, A., Fox, P. C. Pilot clinical trial of dehydroepiandrosterone (DHEA) versus placebo for Sjogren's syndrome. Arthritis Rheum
  15. Christiansen, J. J., Andersen, N. H., Sorensen, K. E., Pedersen, E. M., Bennett, P., Andersen, M., Christiansen, J. S., Jorgensen, J. O., Gravholt, C. H. Dehydroepiandrosterone substitution in female adrenal failure: no impact on endothelial function and
  16. Panjari, M., Bell, R. J., Jane, F., Wolfe, R., Adams, J., Morrow, C., Davis, S. R. A randomized trial of oral DHEA treatment for sexual function, well-being, and menopausal symptoms in postmenopausal women with low libido. J Sex Med 2009;6(9):2579-90.
  17. Mamas, L., Mamas, E. Dehydroepiandrosterone supplementation in assisted reproduction: rationale and results. Curr Opin Obstet Gynecol 2009;21(4):306-8.
  18. Hartkamp, A., Geenen, R., Godaert, G. L., Bootsma, H., Kruize, A. A., Bijlsma, J. W., Derksen, R. H. Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjogren syndrome: a randomised controlled tr
  19. Yeung, T. W., Li, R. H., Lee, V. C., Ho, P. C., Ng, E. H. A randomized double-blinded placebo-controlled trial on the effect of dehydroepiandrosterone for 16 weeks on ovarian response markers in women with primary ovarian insufficiency. J Clin Endocrinol
  20. Kocis, P. Prasterone. Am J Health Syst.Pharm. 11-15-2006;63(22):2201-2210.
  21. Rice, S. P., Agarwal, N., Bolusani, H., Newcombe, R., Scanlon, M. F., Ludgate, M., and Rees, D. A. Effects of dehydroepiandrosterone replacement on vascular function in primary and secondary adrenal insufficiency: a randomized crossover trial. J Clin End
  22. Chen, M. J., Chen, C. D., Yang, J. H., Chen, C. L., Ho, H. N., Yang, W. S., and Yang, Y. S. High serum dehydroepiandrosterone sulfate is associated with phenotypic acne and a reduced risk of abdominal obesity in women with polycystic ovary syndrome. Hum.
  23. Yeung TW, Chai J, Li RH, et al. A randomized, controlled, pilot trial on the effect of dehydroepiandrosterone on ovarian response markers, ovarian response, and in vitro fertilization outcomes in poor responders. Fertil Steril 2014;102(1):108-115.e1.
  24. Chen SN, Tsui KH, Wang PH, Chern CU, Wen ZH, Lin LT. Dehydroepiandrosterone supplementation improves the outcomes of in vitro fertilization cycles in older patients with diminished ovarian reserve. Front Endocrinol (Lausanne). 2019;10:800.
  25. El-Alfy, M., Deloche, C., Azzi, L., Bernard, B. A., Bernerd, F., Coutet, J., Chaussade, V., Martel, C., Leclaire, J., and Labrie, F. Skin responses to topical dehydroepiandrosterone: implications in antiageing treatment? Br.J Dermatol. 2010;163(5):968-97
  26. Alkatib AA, Cosma M, Elamin MB, et al. A systematic review and meta-analysis of randomized placebo-controlled trials of DHEA treatment effects on quality of life in women with adrenal insufficiency. J Clin Endocrinol Metab 2009;94:3676-81.
  27. Gurnell, E. M., Hunt, P. J., Curran, S. E., Conway, C. L., Pullenayegum, E. M., Huppert, F. A., Compston, J. E., Herbert, J., Chatterjee, V. K. Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial. J Clin Endocrinol
  28. Christiansen, J. J., Bruun, J. M., Christiansen, J. S., Jorgensen, J. O., Gravholt, C. H. Long-term DHEA substitution in female adrenocortical failure, body composition, muscle function, and bone metabolism: a randomized trial. Eur J Endocrinol 2011;165(2
  29. Penisson-Besnier, I., Devillers, M., Porcher, R., Orlikowski, D., Doppler, V., Desnuelle, C., Ferrer, X., Bes, M. C., Bouhour, F., Tranchant, C., Lagrange, E., Vershueren, A., Uzenot, D., Cintas, P., Sole, G., Hogrel, J. Y., Laforet, P., Vial, C., Vila, A
  30. Binder, G., Weber, S., Ehrismann, M., Zaiser, N., Meisner, C., Ranke, M. B., Maier, L., Wudy, S. A., Hartmann, M. F., Heinrich, U., Bettendorf, M., Doerr, H. G., Pfaeffle, R. W., Keller, E. Effects of dehydroepiandrosterone therapy on pubic hair growth an
  31. Artini, P. G., Simi, G., Ruggiero, M., Pinelli, S., Di Berardino, O. M., Papini, F., Papini, S., Monteleone, P., Cela, V. DHEA supplementation improves follicular microenviroment in poor responder patients. Gynecol Endocrinol 2012;28(9):669-73.
Anxiety Psychiatric

DHEA-induced mania has been reported. Clinical studies have also reported anxiety, nervousness, irritability, emotional change, and depression in patients receiving DHEA.

  1. Kline MD, Jaggers ED. Mania onset while using dehydroepiandrosterone (letter). Am J Psychiatry 1999;156:971.
  2. Markowitz JS, Carson WH, Jackson CW. Possible dihydroepiandrosterone-induced mania. Biol Psychiatry 1999;45:241-2.
  3. Dean CE. Prasterone (DHEA) and mania. Ann Pharmacother 2000;34:1419-22.
  4. Vacheron-Trystram, M. N., Cheref, S., Gauillard, J., Plas, J. [A case report of mania precipitated by use of DHEA]. Encephale 2002;28(6 Pt 1):563-6.
  5. Van Vollenhoven RF, Engleman EG, McGurie JL. Dehydroepiandrosterone in Systemic Lupus Erythematosus. Arth Rheum 1995;38:1826-31.
  6. Pillemer, S. R., Brennan, M. T., Sankar, V., Leakan, R. A., Smith, J. A., Grisius, M., Ligier, S., Radfar, L., Kok, M. R., Kingman, A., Fox, P. C. Pilot clinical trial of dehydroepiandrosterone (DHEA) versus placebo for Sjogren's syndrome. Arthritis Rheum
  7. Christiansen, J. J., Andersen, N. H., Sorensen, K. E., Pedersen, E. M., Bennett, P., Andersen, M., Christiansen, J. S., Jorgensen, J. O., Gravholt, C. H. Dehydroepiandrosterone substitution in female adrenal failure: no impact on endothelial function and
  8. Binder, G., Weber, S., Ehrismann, M., Zaiser, N., Meisner, C., Ranke, M. B., Maier, L., Wudy, S. A., Hartmann, M. F., Heinrich, U., Bettendorf, M., Doerr, H. G., Pfaeffle, R. W., Keller, E. Effects of dehydroepiandrosterone therapy on pubic hair growth an
Arrhythmia Cardiovascular

Incidences of arrhythmia, chest pain, palpitations, hypertension, and transient ischemic attacks have been reported. DHEA has also been found to decrease high-density lipoprotein (HDL) levels and increase triglycerides.

  1. Penisson-Besnier, I., Devillers, M., Porcher, R., Orlikowski, D., Doppler, V., Desnuelle, C., Ferrer, X., Bes, M. C., Bouhour, F., Tranchant, C., Lagrange, E., Vershueren, A., Uzenot, D., Cintas, P., Sole, G., Hogrel, J. Y., Laforet, P., Vial, C., Vila, A
  2. Sahelian, R. and Borken, S. Dehydroepiandrosterone and cardiac arrhythmia. Ann Intern.Med 10-1-1998;129(7):588.
  3. von Muhlen D., Laughlin, G. A., Kritz-Silverstein, D., Bergstrom, J., Bettencourt, R. Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial. Osteoporos Int 2008;19(5):
  4. Kritz-Silverstein, D., von, Muhlen D., Laughlin, G. A., Bettencourt, R. Effects of dehydroepiandrosterone supplementation on cognitive function and quality of life: the DHEA and Well-Ness (DAWN) Trial. J Am Geriatr Soc 2008;56(7):1292-8.
  5. Jankowski, C. M., Gozansky, W. S., Schwartz, R. S., Dahl, D. J., Kittelson, J. M., Scott, S. M., Van Pelt, R. E., Kohrt, W. M. Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: a randomized, controlled trial. J
  6. Forsblad-d'Elia, H., Carlsten, H., Labrie, F., Konttinen, Y. T., Ohlsson, C. Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentration
  7. Kocis, P. Prasterone. Am J Health Syst.Pharm. 11-15-2006;63(22):2201-2210.
  8. Casson, P. R., Santoro, N., Elkind-Hirsch, K., Carson, S. A., Hornsby, P. J., Abraham, G., Buster, J. E. Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-I and decreases high-density lipoprotein: a six-month t
  9. Araneo, B. Daynes, R. Dehydroepiandrosterone functions as more than an antiglucocorticoid in preserving immunocompetence after thermal injury. Endocrinology 1995;136(2):393-401.
  10. Nordmark, G., Bengtsson, C., Larsson, A., Karlsson, F. A., Sturfelt, G., Ronnblom, L. Effects of dehydroepiandrosterone supplement on health-related quality of life in glucocorticoid treated female patients with systemic lupus erythematosus. Autoimmunity
  11. Srinivasan, M., Irving, B. A., Frye, R. L., O'Brien, P., Hartman, S. J., McConnell, J. P., Nair, K. S. Effects on lipoprotein particles of long-term dehydroepiandrosterone in elderly men and women and testosterone in elderly men. J Clin Endocrinol Metab 2
  12. Srinivasan, M., Irving, B. A., Dhatariya, K., Klaus, K. A., Hartman, S. J., McConnell, J. P., Nair, K. S. Effect of dehydroepiandrosterone replacement on lipoprotein profile in hypoadrenal women. J Clin Endocrinol Metab 2009;94(3):761-4.
  13. Jankowski, C. M., Gozansky, W. S., Van Pelt, R. E., Wolfe, P., Schwartz, R. S., Kohrt, W. M. Oral dehydroepiandrosterone replacement in older adults: effects on central adiposity, glucose metabolism and blood lipids. Clin Endocrinol (Oxf) 2011;75(4):456-6
Benign prostatic hyperplasia (BPH) Genitourinary

In older adults, elevated and severe urinary symptoms (as evidenced by scores of more than 20, using the American Urological Association Symptom Index for Benign Prostatic Hyperplasia [International Prostate Symptom Score]) and urinary tract infection were reported. Rare incidences of abnormal menses and increased discharge have been reported. DHEA has been associated with hematuria.

  1. Jankowski, C. M., Gozansky, W. S., Schwartz, R. S., Dahl, D. J., Kittelson, J. M., Scott, S. M., Van Pelt, R. E., Kohrt, W. M. Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: a randomized, controlled trial. J
  2. Van Vollenhoven RF, Engleman EG, McGurie JL. Dehydroepiandrosterone in Systemic Lupus Erythematosus. Arth Rheum 1995;38:1826-31.
  3. Artini, P. G., Simi, G., Ruggiero, M., Pinelli, S., Di Berardino, O. M., Papini, F., Papini, S., Monteleone, P., Cela, V. DHEA supplementation improves follicular microenviroment in poor responder patients. Gynecol Endocrinol 2012;28(9):669-73.
  4. Kocis, P. Prasterone. Am J Health Syst.Pharm. 11-15-2006;63(22):2201-2210.
Breast cancer Oncologic

Preclinical research suggests that DHEA may increase the risk of cancer, particularly prostate, liver, breast, and pancreatic cancers. High concentrations of DHEA in postmenopausal patients have been associated with an increased risk of breast cancer.

  1. Kuritzky L. DHEA: Science or wishful thinking? Hosp Pract 1998;33:85-6.
  2. Calhoun KE, Pommier RF, Muller P, et al. Dehydroepiandrosterone sulfate causes proliferation of estrogen receptor-positive breast cancer cells despite treatment with fulvestrant. Arch Surg 2003;138:879-83..
  3. Morris KT, Toth-Fejel S, Schmidt J, et al. High dehydroepiandrosterone-sulfate predicts breast cancer progression during new aromatase inhibitor therapy and stimulates breast cancer cell growth in tissue culture: a renewed role for adrenalectomy. Surgery
  4. Calhoun K, Pommier R, Cheek J, et al. The effect of high dehydroepiandrosterone sulfate levels on tamoxifen blockade and breast cancer progression. Am J Surg 2003;185:411-5..
  5. Acacio BD, Stanczyk FZ, Mullin P, et al. Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term daily oral administration to healthy young men. Fertil Steril 2004;81:595-604.
  6. von Muhlen D., Laughlin, G. A., Kritz-Silverstein, D., Bergstrom, J., Bettencourt, R. Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial. Osteoporos Int 2008;19(5):
  7. Kritz-Silverstein, D., von, Muhlen D., Laughlin, G. A., Bettencourt, R. Effects of dehydroepiandrosterone supplementation on cognitive function and quality of life: the DHEA and Well-Ness (DAWN) Trial. J Am Geriatr Soc 2008;56(7):1292-8.
  8. Penisson-Besnier, I., Devillers, M., Porcher, R., Orlikowski, D., Doppler, V., Desnuelle, C., Ferrer, X., Bes, M. C., Bouhour, F., Tranchant, C., Lagrange, E., Vershueren, A., Uzenot, D., Cintas, P., Sole, G., Hogrel, J. Y., Laforet, P., Vial, C., Vila, A
  9. Rao, M. S., Subbarao, V., Yeldandi, A. V., and Reddy, J. K. Hepatocarcinogenicity of dehydroepiandrosterone in the rat. Cancer Res. 5-15-1992;52(10):2977-2979.
  10. Tagliaferro, A. R., Roebuck, B. D., Ronan, A. M., and Meeker, L. D. Enhancement of pancreatic carcinogenesis by dehydroepiandrosterone. Adv.Exp.Med Biol. 1992;322:119-129.
  11. Mizokami, A., Koh, E., Izumi, K., Narimoto, K., Takeda, M., Honma, S., Dai, J., Keller, E. T., and Namiki, M. Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of testosterone and dihydrotestoster
  12. Liu, X., Arnold, J. T., and Blackman, M. R. Dehydroepiandrosterone administration or G{alpha}q overexpression induces {beta}-catenin/T-Cell factor signaling and growth via increasing association of estrogen receptor-{beta}/Dishevelled2 in androgen-indepe
  13. Goldberg, M. Dehydroepiandrosterone, insulin-like growth factor-I, and prostate cancer. Ann Intern Med 10-1-1998;129(7):587-588.
  14. Ebeling P, Koivisto VA. Physiological importance of dehydroepiandrosterone. Lancet 1994;343:1479-81.
  15. Stoll BA. Dietary supplements of dehydroepiandrosterone in relation to breast cancer risk. Eur J Clin Nutr 1999;53:771-5.
Cough Pulmonary/Respiratory

Increased cough and nasal congestion have been noted in human research. A report of acute respiratory failure was made in clinical study evaluating the use of DHEA in patients with myotonic dystrophy (type 1).

  1. Penisson-Besnier, I., Devillers, M., Porcher, R., Orlikowski, D., Doppler, V., Desnuelle, C., Ferrer, X., Bes, M. C., Bouhour, F., Tranchant, C., Lagrange, E., Vershueren, A., Uzenot, D., Cintas, P., Sole, G., Hogrel, J. Y., Laforet, P., Vial, C., Vila, A
Diarrhea Gastrointestinal

Gastrointestinal disturbances such as nausea, diarrhea, and abdominal discomfort have been noted in human research.

Epilepsy Neurologic/CNS

In humans, dizziness, fatigue, malaise, sleep disturbances, increased dreaming, night sweats, restlessness, "painful spots," and a crawling scalp sensation have been reported. There is a case of seizure associated with DHEA use in a 30 year-old female with fragile X syndrome and no history of convulsive disorder who used DHEA to try to improve ovarian production.

  1. Karp, G., Bentov, Y., Masalha, R., and Ifergane, G. Onset of late posttraumatic seizure after dehydroepiandrosterone treatment. Fertil.Steril. 2009;91(3):931-932.
Myalgia Musculoskeletal

Incidences of asthenia, arthralgia, and myalgia, including calf cramps, have been reported.

Myasthenia gravis Endocrine

In postmenopausal patients, high doses of DHEA (1600 mg daily) induced insulin resistance, reportedly due to increased androgen levels that occurred during supplementation.

  1. Mortola, J. F. Yen, S. S. The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. J Clin Endocrinol Metab 1990;71(3):696-704.
Pain Ocular/Otic

In patients with Sjögren syndrome, maculae lesions, ocular pain and dryness, and painful eye exams have been reported.

  1. Pillemer, S. R., Brennan, M. T., Sankar, V., Leakan, R. A., Smith, J. A., Grisius, M., Ligier, S., Radfar, L., Kok, M. R., Kingman, A., Fox, P. C. Pilot clinical trial of dehydroepiandrosterone (DHEA) versus placebo for Sjogren's syndrome. Arthritis Rheum
  2. Hartkamp, A., Geenen, R., Godaert, G. L., Bootsma, H., Kruize, A. A., Bijlsma, J. W., Derksen, R. H. Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjogren syndrome: a randomised controlled tr
  3. Virkki, L. M., Porola, P., Forsblad-d'Elia, H., Valtysdottir, S., Solovieva, S. A., Konttinen, Y. T. Dehydroepiandrosterone (DHEA) substitution treatment for severe fatigue in DHEA-deficient patients with primary Sjogren's syndrome. Arthritis Care Res (Ho
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no single standard dose of DHEA, and the right amount depends on the reason for use, the person, and the product. Doses used in research vary widely.

If you and your healthcare provider decide DHEA is appropriate, follow the directions on the product label and use the lowest amount that meets your needs. The prescription vaginal product (prasterone) has its own specific dosing set by a doctor.

Because DHEA is a hormone, it is wise to have a pharmacist or doctor guide your dose rather than self-prescribing. Do not assume a higher dose is safer or more effective.

Pregnancy & Breastfeeding
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 98 references that drive our Dhea monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Frye RF, Kroboth PD, Folan MM, et al. Effect of DHEA on CYP3A-mediated metabolism of triazolam. Clin Pharmacol Ther 2000;67:109 (abstract PI-82).
  2. Kuritzky L. DHEA: Science or wishful thinking? Hosp Pract 1998;33:85-6. PubMed
  3. Van Vollenhoven RF, Morabito LM, Engleman EG, et al. Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months. J Rheumatol 1998;25:285-9.
  4. Van Vollenhoven RF, Engleman EG, McGurie JL. Dehydroepiandrosterone in Systemic Lupus Erythematosus. Arth Rheum 1995;38:1826-31. DOI
  5. Ebeling P, Koivisto VA. Physiological importance of dehydroepiandrosterone. Lancet 1994;343:1479-81. PubMed
  6. Yen SS, Morales AJ, Khorram O. Replacement of DHEA in aging men and women. Potential remedial effects. Ann N Y Acad Sci 1995;774:128-42. PubMed
  7. Labrie F, Diamond P, Cusan L, et al. Effect of 12 month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women. J Clin Endocrinol Metab 1997;82:3498-505. PubMed
  8. Casson PR, Faquin LC, Stentz FB. Replacement of dehydroepiandrosterone enhances T-lymphocyte insulin binding in postmenopausal women. (abstract) Fertil Steril 1995;63:1027-31. DOI
  9. Morales AJ, Haubrich RH, Hwang JY, et al. The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin Endocrinol (Oxf)1 PubMed
  10. Arlt W, Justl H, Callies F, et al. Oral dehydroepiandrosterone for adrenal androgen replacement: pharmacokinetics and peripheral conversion to androgens and estrogens in young healthy females after dexamethasone suppression. [Abstract] J Clin Endocrinol PubMed
  11. Kline MD, Jaggers ED. Mania onset while using dehydroepiandrosterone (letter). Am J Psychiatry 1999;156:971. PubMed
  12. Callies F, Arlt W, Siekmann L, et al. Influence of oral dehydroepiandrosterone (DHEA) on urinary steroid metabolites in males and females. Steroids 2000;65:98-102. PubMed
  13. Markowitz JS, Carson WH, Jackson CW. Possible dihydroepiandrosterone-induced mania. Biol Psychiatry 1999;45:241-2. PubMed
  14. Stoll BA. Dietary supplements of dehydroepiandrosterone in relation to breast cancer risk. Eur J Clin Nutr 1999;53:771-5. PubMed
  15. Dean CE. Prasterone (DHEA) and mania. Ann Pharmacother 2000;34:1419-22. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Dhea

274 brands in our database make a supplement containing Dhea.

Product directory

Supplement products with Dhea

945 products in our database contain Dhea. Open any to see its full ingredient list and every drug interaction we check.

DHEA 25 by NutriCology Tablet Or Pill 60 scored tablet(s) Off market View ingredients & interactions DHEA 25 by ProCaps Laboratories Capsule 240 Easy-To-Swallow Capsule(s) Off market View ingredients & interactions DHEA 25 by NutraBio Capsule 150 Capsule(s) Off market View ingredients & interactions DHEA 25 25 mg by NutraBio Capsule 150 Capsule(s) Off market View ingredients & interactions DHEA 25 25 Milligrams by NutraBio Capsule 150 Cap(s) Off market View ingredients & interactions DHEA 25 Dehydroepiandrosterone by ProCaps Laboratories Capsule 240 Easy-To-Swallow Capsule(s) Off market View ingredients & interactions DHEA 25 mg by Jarrow Formulas Capsule 90 Veggie Cap(s) Off market View ingredients & interactions DHEA 25 mg by MRM Capsule 60 Vegan Capsule(s) Off market View ingredients & interactions DHEA 25 mg by MRM Capsule 90 Vegan Capsule(s) Off market View ingredients & interactions DHEA 25 mg by Natrol Tablet Or Pill 300 Tablet(s) Off market View ingredients & interactions DHEA 25 mg by Life Extension Tablet Or Pill 100 Dissolve in Mouth Tablet(s) Off market View ingredients & interactions DHEA 25 mg by Vitamin Discount Center Capsule 120 Capsule(s) Off market View ingredients & interactions DHEA 25 mg by Good 'N Natural Tablet Or Pill 100 Tablet(s) Off market View ingredients & interactions DHEA 25 mg by Douglas Laboratories Capsule 100 Vegetarian Capsule(s) Off market View ingredients & interactions DHEA 25 mg by GNC Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions DHEA 25 mg by Jarrow Formulas Capsule 90 Capsule(s) · 25 mg Off market View ingredients & interactions DHEA 25 mg by The Vitamin Shoppe Capsule 120 Capsule(s) Off market View ingredients & interactions DHEA 25 mg by MRM Capsule 60 Vegetarian Capsule(s) Off market View ingredients & interactions DHEA 25 mg by MRM Capsule 90 Vegetarian Capsule(s) Off market View ingredients & interactions DHEA 25 mg by The Vitamin Shoppe Capsule 60 Capsule(s) Off market View ingredients & interactions DHEA 25 mg by MRM Capsule 90 Vegetarian Capsule(s) Off market View ingredients & interactions DHEA 25 mg by OL Olympian Labs, Inc. Capsule 90 Vegetarian Capsule(s) Off market View ingredients & interactions DHEA 25 mg by Natrol Capsule 90 Capsule(s) Off market View ingredients & interactions DHEA 25 mg by Natrol Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions
Pharmacist Counseling Corner

Dhea: Common Questions

What is Dhea used for, and does it work?
People use Dhea for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Dhea for Vaginal atrophy, Aging skin, Depression and Infertility. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Dhea interact with prescription medications?
Yes. We list 776 medications with a known interaction with Dhea. Use the checker above to see how Dhea interacts with a specific drug.
How are Dhea interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Dhea with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Dhea interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Dhea used for?
People use Dhea for anti-aging, mood, low energy, sexual and vaginal health, fertility, and athletic performance, but solid evidence is limited for most of these. A prescription vaginal form is approved for painful sex after menopause.
Is Dhea safe to take?
Because Dhea is a hormone, it can cause side effects like acne, hair changes, and hormonal effects, and it may not be safe for people with hormone-sensitive cancers. It is best used only with guidance from a pharmacist or doctor.
Can I take Dhea if I am pregnant or breastfeeding?
No. Dhea changes hormone levels and is considered unsafe in pregnancy, and there is not enough information to consider it safe while breastfeeding, so it should be avoided.
Is Dhea from wild yam the same as a Dhea supplement?
Not exactly. Dhea supplements may be made in a lab starting from wild yam or soy compounds, but eating wild yam itself does not raise your Dhea levels.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Dhea

A rotating sample of real supplements in our database that list Dhea — open any to see its full ingredients and every drug interaction we check.

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