Herb & supplement monograph

Devil's Claw Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Devil's Claw interacts with medications. The heart of this page is the interaction list — every drug Devil's Claw is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Devil's Claw is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Devil's Claw Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Devil's Claw drug interaction appears low for most people. None of the listed interactions are rated major, and nearly all rest on lab research rather than documented effects in people.

Interactions deserving the most attention

The pairing that stands out most is warfarin, where one case report described unusual bruising that could suggest excess blood thinning, though other factors may have played a role. Because Devil's Claw may inhibit several enzymes the body uses to clear medications, it could in theory raise levels of many prescription drugs, which matters most for narrow-margin medicines. Devil's Claw may also increase stomach acid, so it could modestly work against acid-reducing medications such as H2-blockers and PPIs.

What the rest of the list means

The long list of interactions here mostly reflects one theory applied broadly: lab studies suggest Devil's Claw may affect enzymes and a transporter that process hundreds of medications. None of these predicted effects has been confirmed in humans, so most combinations are unlikely to cause a noticeable problem, but caution is still sensible with closely monitored drugs.

Check your medications against Devil's Claw

Based on HelloPharmacist’s Devil's Claw interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Devil's Claw

804 medications have a known interaction with Devil's Claw, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
Ado-trastuzumab EmtansineKadcyla
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Ado-trastuzumab Emtansine interaction Ado-trastuzumab Emtansine drug page: uses, dosage & side effects
AbemaciclibVerzenio
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Abemaciclib interaction Abemaciclib drug page: uses, dosage & side effects
Abiraterone
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Abiraterone interaction Abiraterone drug page: uses, dosage & side effects
Abiraterone AcetateYonsa, Zytiga
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Abiraterone Acetate interaction Abiraterone Acetate drug page: uses, dosage & side effects
AbrocitinibCibinqo
Moderate Cytochrome P450 2c19 (cyp2c19) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C19.

Read the full Devil's Claw + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AcalabrutinibCalquence
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acalabrutinib interaction Acalabrutinib drug page: uses, dosage & side effects
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Butalbital, Caffeine interaction Acetaminophen, Butalbital, Caffeine drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Caffeine, IsomethepteneMigralam
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Caffeine, Isometheptene interaction
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Caffeine, Pyrilamine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Chlorpheniramine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interaction
Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Chlorpheniramine, Pseudoephedrine interaction
Acetaminophen, DextromethorphanTylenol Cough Ex Strength
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Dextromethorphan interaction
Acetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full Devil's Claw + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Devil's Claw combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Devil's Claw affects

Every type of medication (drug category) Devil's Claw is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 7 drug categories Devil's Claw interacts with
Cytochrome P450 2c19 (cyp2c19) SubstratesCytochrome P450 2c9 (cyp2c9) SubstratesCytochrome P450 3a4 (cyp3a4) SubstratesWarfarin (coumadin)H2-blockersP-glycoprotein SubstratesProton Pump Inhibitors (ppis)
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that devil's claw might inhibit CYP2C19, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that devil's claw might inhibit CYP2C9, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that devil's claw might inhibit CYP3A4, although this has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, Devil's claw might increase the activity of warfarin.
In one case report, purpura occurred in a patient taking warfarin and devil's claw concurrently. This might indicate over-anticoagulation. It is unclear if this was due to Devil's claw or other contributing factors.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, devil's claw might decrease the effectiveness of H2-blockers.
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of H2-blockers.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, devil's claw might increase levels of P-glycoprotein substrates.
In vitro research shows that devil's claw inhibits P-glycoprotein, which transports many drugs out of cells. This might increase intracellular levels of P-glycoprotein substrates, although it is unclear if this effect would be clinically important.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, devil's claw might decrease the effectiveness of PPIs.
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of PPIs.

Likelihood Possible Evidence D
Monograph

Devil's Claw: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Devil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of discomfort. The evidence is moderate at best, and product strength varies, so talk with your pharmacist or doctor before trying it, especially if you have a health condition or take medications.

Devil's Claw
Scientific name
Harpagophytum procumbens
Family
Pedaliaceae
Part used
Dried secondary (tuberous) roots
Common forms
Capsules, tablets, dried root, tea, liquid extracts, and tinctures
People commonly use it for
  • Osteoarthritis pain
  • Lower back pain
  • Joint pain and stiffness
  • General inflammation
  • Digestive upset and loss of appetite

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated for short-term use in healthy adults, but it can cause digestive upset and isn't right for everyone.

PregnancyPossibly Unsafe

When used orally. Anecdotal evidence suggests that devil's claw has oxytocic effects in humans. Also, in vitro research shows that moderate to high do...

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Devil's claw (Harpagophytum procumbens) is a plant native to the dry regions of southern Africa, including the Kalahari Desert and parts of Namibia and South Africa. It belongs to the sesame family (Pedaliaceae). The plant gets its name from the small hooked, claw-like fruit it produces.

The part used in supplements is the dried secondary root, sometimes called the tuber. People have used devil's claw in traditional African medicine for many years for pain, fever, and digestive complaints.

Today it is most often taken as a capsule, tablet, tea, or liquid extract for joint and back pain. Many products are standardized to a compound called harpagoside.

How it works

Devil's claw contains compounds called iridoid glycosides, the best known being harpagoside. These are thought to be the main active ingredients.

Laboratory and animal research suggests these compounds may lower the body's production of certain inflammatory chemicals, which could reduce pain and swelling. This is why devil's claw is often marketed as a natural anti-inflammatory.

It is important to know that much of this understanding comes from test-tube and animal studies. Exactly how it works in the human body, and how much of the active compound reaches the joints, is still not fully understood.

Effectiveness

Does Devil's Claw work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 13 uses evaluated
2 Possibly effective 11 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Back pain
Rating & evidence shown verbatim from Natural Medicines

Taking devil's claw orally seems to lessen nonspecific low-back pain.

Possibly Effective Osteoarthritis
Rating & evidence shown verbatim from Natural Medicines

Taking devil's claw orally, alone or in conjunction with nonsteroidal anti-inflammatory drugs (NSAIDs), seems to help decrease osteoarthritis pain.

Also studied for 11 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Atherosclerosis
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral devil's claw for atherosclerosis, there is insufficient reliable information about the clinical effects of devil's claw for this purpose.

Insufficient Reliable Evidence To Rate Dysmenorrhea
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral devil's claw for dysmenorrhea, there is insufficient reliable information about the clinical effects of devil's claw for this purpose.

Insufficient Reliable Evidence To Rate Dyspepsia
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral devil's claw for dyspepsia, there is insufficient reliable information about the clinical effects of devil's claw for this purpose.

Insufficient Reliable Evidence To Rate Fibromyalgia
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral devil's claw for fibromyalgia, there is insufficient reliable information about the clinical effects of devil's claw for this condition.

Insufficient Reliable Evidence To Rate Gout
Rating & evidence shown verbatim from Natural Medicines

Oral devil's claw root extract has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Migraine headache
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral devil's claw for migraine headache, there is insufficient reliable information about the clinical effects of devil's claw for this purpose.

Insufficient Reliable Evidence To Rate Myalgia
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral devil's claw for myalgia, there is insufficient reliable information about the clinical effects of devil's claw for this purpose.

Insufficient Reliable Evidence To Rate Parturition
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral devil's claw for parturition, there is insufficient reliable information about the clinical effects of devil's claw for this purpose.

Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral devil's claw is beneficial in patients with RA.

Insufficient Reliable Evidence To Rate Tendinopathy
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral devil's claw for tendinopathy, there is insufficient reliable information about the clinical effects of devil's claw for this purpose.

Insufficient Reliable Evidence To Rate Wound healing
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical devil's claw for wound healing, there is insufficient reliable information about the clinical effects of devil's claw for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Devil's claw is generally considered well tolerated for short-term use in healthy adults. Still, some people should be careful.

Because it may increase stomach acid, people with stomach or duodenal ulcers or other digestive problems should use caution. It may also affect blood sugar, blood pressure, and heart rhythm, so people with diabetes, heart conditions, or gallstones should check with a healthcare provider first.

It is best to avoid devil's claw during pregnancy, since it may affect the uterus, and to avoid it while breastfeeding because there is not enough safety information. Stop taking it before any planned surgery and let your care team know you have been using it.

Side effects

The most common side effect is digestive upset, such as diarrhea, nausea, stomach pain, or heartburn.

Less commonly, people report headache, dizziness, ringing in the ears, or changes in appetite. Allergic reactions are possible but uncommon.

Stop taking it and seek medical care if you have signs of a serious allergic reaction, such as rash, swelling, or trouble breathing, or if you develop severe stomach pain.

Devil's Claw: Reported Adverse Effects

Documented safety reports on Devil's Claw from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, Devil's claw seems to be generally well tolerated.

Most Common Adverse Effects:

Orally: Allergic skin reactions, diarrhea, dyspepsia.

Serious Adverse Effects (Rare):

Orally: Gastrointestinal bleeding.

Reports by condition
Anorexia Neurologic/CNS

In a trial of devil's claw, one patient withdrew after 4 days of therapy due to a throbbing frontal headache, as well as tinnitus, anorexia, and loss of taste. Rarely, dizziness, somnolence, and insomnia have been reported. It is unclear if these symptoms were caused by devil's claw.

  1. Grahame R, Robinson BV. Devils's claw (Harpagophytum procumbens): pharmacological and clinical studies. Ann Rheum Dis 1981;40:632.
  2. Laudahn, D. and Walper, A. Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain. Phytother.Res. 2001;15(7):621-624.
  3. Chrubasik S, Model A, Black A, and et al. A randomized double-blind pilot study comparing Doloteffin® and Vioxx® in the treatment of low back pain. Rheumatology 2003;42:141-148.
Anorexia Gastrointestinal

Gastrointestinal side effects, including mild gastrointestinal upset, diarrhea, anorexia, acid reflux, or loss of taste, have been reported in some individuals receiving devil's claw, especially at high doses. Gastrointestinal complaints have been reported in 9% to 18% of patients taking a specific devil's claw extract (Doloteffin, Ardeypharm), while diarrhea was reported in about 8% of patients taking devil's claw (Harpadol, Arkopharma). Several cases of gastrointestinal bleeding have been reported.

  1. Chantre P, Cappelaere A, Leblan D, et al. Efficacy and tolerance or Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000;7:177-83.
  2. Chrubasik S, Thanner J, Kunzel O, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002;9:181-94.
  3. Grahame R, Robinson BV. Devils's claw (Harpagophytum procumbens): pharmacological and clinical studies. Ann Rheum Dis 1981;40:632.
  4. Wegener T, Lupke NP. Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC). Phytother Res 2003;17:1165-72.
  5. Chrubasik S, Kunzel O, Thanner J, et al. A 1-year follow-up after a pilot study with Doloteffin for low back pain. Phytomedicine 2005;12:1-9.
  6. Chrubasik, S., Junck, H., Breitschwerdt, H., Conradt, C., and Zappe, H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double- blind study. Eur.J Anaesthesiol. 1999;16(2
  7. Laudahn, D. and Walper, A. Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain. Phytother.Res. 2001;15(7):621-624.
  8. Belaiche P. Etude clinique de 630 cas d'artrose traites par le nebulisat aqueux d'Harpagophytum procumbens (Radix). Phytotherapy 1982;1:22-28.
  9. Chrubasik S, Model A, Black A, and et al. A randomized double-blind pilot study comparing Doloteffin® and Vioxx® in the treatment of low back pain. Rheumatology 2003;42:141-148.
  10. Anon. Devil's claw root: ulcers and gastrointestinal bleeding. Prescrire Int 2013;22(144):296.
Anxiety Psychiatric

Rarely, anxiety has been reported in patients taking devil's claw.

  1. Chrubasik S, Thanner J, Kunzel O, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002;9:181-94.
Dysmenorrhea Genitourinary

Dysmenorrhea was reported in one patient taking a specific devil's claw extract (Doloteffin, Ardeypharm) for 8 weeks.

  1. Chrubasik S, Thanner J, Kunzel O, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002;9:181-94.
Hypertension Cardiovascular

In one case report, a healthy patient with normal blood pressure presented with hypertension after taking devil's claw 250 mg twice daily for 2 weeks. It gradually resolved after discontinuation of devil's claw. Some animal research shows that devil's claw might have negative chronotropic, as well as positive and negative inotropic, effects. However, these effects have not been documented in humans.

  1. Cuspidi C, Sala C, Tadic M, et al. Systemic hypertension induced by Harpagophytum procumbens (devil's claw): a case report. J Clin Hypertens (Greenwich) 2015;17(11):908-10.
  2. Circosta C, Occhiuto F, Ragusa S, et al. A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity. J Ethnopharmacol 1984;11:259-74.
Nausea and vomiting Endocrine

In one case report, a 65-year-old female developed psychomotor agitation, nausea, and distress from euvolemic hyponatremia secondary to inappropriate secretion of antidiuretic hormone (SIADH) within 1 month of starting daily treatment with devil's claw. Within 5 days of discontinuing the product and receiving sodium replacement, the symptoms resolved. Two months later, the patient re-initiated devil's claw and again developed euvolemic hyponatremia.

  1. Carvalho RR, Donadel CD, Cortez AF, Valviesse VR, Vianna PF, Correa BB. J Bras Nefrol. 2017 Mar;39(1):79-81.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no single official dose for devil's claw. Many products are standardized to their harpagoside content, but the amount varies a lot from one brand to another.

The safest approach is to follow the directions on the product label and not take more than recommended. Capsules, tablets, teas, and liquid extracts are all used, and the right amount depends on the specific product.

Because strength and quality differ between brands, it is a good idea to check with your pharmacist before starting, and to choose products from reputable companies that test their supplements.

Pregnancy & Breastfeeding

Devil's Claw & Pregnancy

Possibly Unsafe

When used orally. Anecdotal evidence suggests that devil's claw has oxytocic effects in humans. Also, in vitro research shows that moderate to high doses of devil's claw root extract induce contractions of isolated uterine muscle from pregnant and nonpregnant rats; avoid using.

  1. Mahomed IM, Ojewole JAO. Oxytocin-like effect of Harpagophytum procumbens [Pedaliacae] secondary root aqueous extract on rat isolated uterus. Afr J Trad CAM 2006;3(1):82-89.

Devil's Claw & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 18 references that drive our Devil's Claw monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Chantre P, Cappelaere A, Leblan D, et al. Efficacy and tolerance or Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000;7:177-83.
  4. Chrubasik S, Thanner J, Kunzel O, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002;9:181-94. PubMed
  5. Circosta C, Occhiuto F, Ragusa S, et al. A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity. J Ethnopharmacol 1984;11:259-74. PubMed
  6. Grahame R, Robinson BV. Devils's claw (Harpagophytum procumbens): pharmacological and clinical studies. Ann Rheum Dis 1981;40:632. PubMed
  7. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  8. Wegener T, Lupke NP. Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC). Phytother Res 2003;17:1165-72.
  9. Chrubasik S, Kunzel O, Thanner J, et al. A 1-year follow-up after a pilot study with Doloteffin for low back pain. Phytomedicine 2005;12:1-9. PubMed
  10. Romiti N, Tramonti G, Corti A, Chieli E. Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein. Phytomedicine 2009;16:1095-100. PubMed
  11. Chrubasik, S., Junck, H., Breitschwerdt, H., Conradt, C., and Zappe, H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double- blind study. Eur.J Anaesthesiol. 1999;16(2 DOI
  12. Laudahn, D. and Walper, A. Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain. Phytother.Res. 2001;15(7):621-624.
  13. Belaiche P. Etude clinique de 630 cas d'artrose traites par le nebulisat aqueux d'Harpagophytum procumbens (Radix). Phytotherapy 1982;1:22-28.
  14. Chrubasik S, Model A, Black A, and et al. A randomized double-blind pilot study comparing Doloteffin® and Vioxx® in the treatment of low back pain. Rheumatology 2003;42:141-148.
  15. Cuspidi C, Sala C, Tadic M, et al. Systemic hypertension induced by Harpagophytum procumbens (devil's claw): a case report. J Clin Hypertens (Greenwich) 2015;17(11):908-10.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Devil's Claw

191 brands in our database make a supplement containing Devil's Claw.

Product directory

Supplement products with Devil's Claw

591 products in our database contain Devil's Claw. Open any to see its full ingredient list and every drug interaction we check.

Joint-Support Formula by Douglas Laboratories Tablet Or Pill 120 Tablet(s) Off market View ingredients & interactions Levare by Ultimaxx Tablet Or Pill 90 Tablet(s) · 600 mg Off market View ingredients & interactions Ligament Restore by Pure Encapsulations Capsule 120 Capsule(s) Off market View ingredients & interactions Ligament Restore by Pure Encapsulations Capsule 240 Capsule(s) Off market View ingredients & interactions Ligament Restore by Pure Encapsulations Capsule 120 Capsule(s) Off market View ingredients & interactions Ligament Restore by Pure Encapsulations Capsule 240 Capsule(s) Off market View ingredients & interactions Ligament Restore by Pure Encapsulations Capsule 120 Capsule(s) Off market View ingredients & interactions Ligament Restore by Pure Encapsulations Capsule 240 Capsule(s) Off market View ingredients & interactions Mobility Essentials by Swanson Condition Specific Formulas Capsule 180 Veggie Capsule(s) Off market View ingredients & interactions Nerve Eight by Nature's Sunshine Capsule 100 Capsule(s) Off market View ingredients & interactions Nerve Eight by Nature's Sunshine Capsule 100 Capsule(s) Off market View ingredients & interactions Nerve Eight by Nature's Sunshine Capsule 100 Capsule(s) Off market View ingredients & interactions Nervous System by Nature's Sunshine Other (e.g. Tea Bag) 300 Capsule(s) · 60 Tablet(s) Off market View ingredients & interactions Ortho-Flex by Pacific BioLogic Capsule 120 Vegetarian Capsule(s) Off market View ingredients & interactions Orthoflex by Pacific BioLogic Capsule 120 Vegetarian Capsule(s) Off market View ingredients & interactions Orthoflex by Pacific BioLogic Capsule 120 Vegetarian Capsule(s) Off market View ingredients & interactions OsteoEZ by Hampshire Labs Capsule 30 Capsule(s) Off market View ingredients & interactions Phyto UltraComfort by Pure Encapsulations Capsule 120 Capsule(s) Off market View ingredients & interactions Phyto UltraComfort by Pure Encapsulations Capsule 60 Capsule(s) Off market View ingredients & interactions Phyto UltraComfort by Pure Encapsulations Capsule 60 Capsule(s) Off market View ingredients & interactions Phyto UltraComfort by Pure Encapsulations Capsule 120 Capsule(s) Off market View ingredients & interactions Recovery Accelerator Apple Berry by Vega Sport Powder 19 oz. · 540 Gram(s) Off market View ingredients & interactions Rejuv-N-8 by Natural Guardian Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions Restorative Joint Support by Cenegenics Capsule 120 Capsule(s) Off market View ingredients & interactions
Pharmacist Counseling Corner

Devil's Claw: Common Questions

What is Devil's Claw used for, and does it work?
People use Devil's Claw for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Devil's Claw for Back pain and Osteoarthritis. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Devil's Claw interact with prescription medications?
Yes. We list 804 medications with a known interaction with Devil's Claw. Use the checker above to see how Devil's Claw interacts with a specific drug.
How are Devil's Claw interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Devil's Claw with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Devil's Claw interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Devil's Claw used for?
It is most often used for arthritis pain, joint stiffness, and lower back pain. Some studies suggest it may help, but the evidence is not strong, and it is not a proven cure.
Is Devil's Claw safe to take?
For most healthy adults, short-term use is generally well tolerated, with stomach upset being the most common complaint. People with ulcers, diabetes, heart problems, or gallstones, and anyone who is pregnant or breastfeeding, should avoid it or check with a healthcare provider first.
How long does it take to work?
In studies of joint and back pain, any benefit usually takes several weeks of regular use to appear. If you do not notice improvement after a reasonable trial, talk with your doctor or pharmacist.
Can I take Devil's Claw during pregnancy?
No. It is best to avoid Devil's Claw during pregnancy because it may affect the uterus, and its safety has not been established. You should also avoid it while breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Devil's Claw

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