Herb & supplement monograph

Goji Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Goji interacts with medications. The heart of this page is the interaction list — every drug Goji is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Goji is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Interaction report

Drugs that interact with Goji

1000 medications have a known interaction with Goji, graded by severity. Select any drug for the full evidence-based detail.

2 major interactions. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with Goji.

2,830 drugs
WarfarinWarfarin
Major Warfarin (coumadin)

Goji can increase the effects of warfarin and possibly increase the risk of bleeding.

Read the full Goji + Warfarin interaction Warfarin drug page: uses, dosage & side effects
Warfarin SodiumCoumadin, Panwarfin, Sofarin
Major Warfarin (coumadin)

Goji can increase the effects of warfarin and possibly increase the risk of bleeding.

Read the full Goji + Warfarin Sodium interaction Warfarin Sodium drug page: uses, dosage & side effects
Ado-trastuzumab EmtansineKadcyla
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Ado-trastuzumab Emtansine interaction Ado-trastuzumab Emtansine drug page: uses, dosage & side effects
AbemaciclibVerzenio
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Abemaciclib interaction Abemaciclib drug page: uses, dosage & side effects
Abiraterone
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Abiraterone interaction Abiraterone drug page: uses, dosage & side effects
Abiraterone AcetateYonsa, Zytiga
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Abiraterone Acetate interaction Abiraterone Acetate drug page: uses, dosage & side effects
AbrocitinibCibinqo
Moderate Cytochrome P450 2c19 (cyp2c19) Substrates

Theoretically, goji berry might inhibit CYP2C19 and reduce metabolism of CYP2C19 substrates.

Read the full Goji + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AcalabrutinibCalquence
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Acalabrutinib interaction Acalabrutinib drug page: uses, dosage & side effects
AcebutololRhotral, Sectral
Moderate Antihypertensive Drugs

Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.

Read the full Goji + Acebutolol interaction Acebutolol drug page: uses, dosage & side effects
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Acetaminophen, Butalbital, Caffeine interaction Acetaminophen, Butalbital, Caffeine drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Butalbital, CodeineBancap w/ Codeine
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.

Read the full Goji + Acetaminophen, Butalbital, Codeine interaction
Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.

Read the full Goji + Acetaminophen, Butalbital, Codeine Phosphate interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.

Read the full Goji + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.

Read the full Goji + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Caffeine, IsomethepteneMigralam
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Acetaminophen, Caffeine, Isometheptene interaction
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Acetaminophen, Caffeine, Pyrilamine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.

Read the full Goji + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.

Read the full Goji + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.

Read the full Goji + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.

Read the full Goji + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Acetaminophen, Chlorpheniramine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full Goji + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Goji combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Goji affects

Every type of medication (drug category) Goji is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 8 drug categories Goji interacts with
Warfarin (coumadin)Antihypertensive DrugsCytochrome P450 2c19 (cyp2c19) SubstratesCytochrome P450 2c9 (cyp2c9) SubstratesCytochrome P450 2d6 (cyp2d6) SubstratesCytochrome P450 3a4 (cyp3a4) SubstratesFlecainide (tambocor)Antidiabetes Drugs
Warfarin (Coumadin)

Goji can increase the effects of warfarin and possibly increase the risk of bleeding.
There are at least 5 case reports of increased international normalized ratio (INR) in patients stabilized on warfarin who began drinking goji juice, concentrated goji tea, or goji wine. Goji may inhibit the metabolism of warfarin by cytochrome P450 2C9 (CYP2C9).

Likelihood Probable Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Animal and in vitro research suggest that goji root bark has hypotensive effects. However, goji fruit juice does not appear to reduce systolic or diastolic blood pressure in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, goji berry might inhibit CYP2C19 and reduce metabolism of CYP2C19 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C19 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2C19 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C9 enzymes. Additionally, multiple case reports suggest that goji berry concentrated tea and juice inhibit the metabolism of warfarin, a CYP2C9 substrate. Concomitant use with goji may decrease metabolism and increase levels of CYP2C9 substrates.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
In vitro research shows that goji berry juice inhibits CYP2D6 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2D6 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
In vitro research shows that goji berry juice inhibits CYP3A4 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP3A4 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D
Flecainide (Tambocor)

Theoretically, goji berry might increase the levels and clinical effects of flecainide.
In one case report, a 75-year-old patient stable on flecainide and warfarin presented to the emergency room with fainting and pleomorphic arrhythmia caused by flecainide toxicity. Flecainide toxicity was attributed to drinking 1-2 glasses of concentrated goji tea daily for 2 weeks. Theoretically, goji may have inhibited the cytochrome P450 2D6 (CYP2D6) metabolism of flecainide.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of goji fruit polysaccharides or goji root bark with antidiabetes drugs might have additive effects.
Animal and in vitro research show that goji root bark and fruit polysaccharides might have hypoglycemic effects. However, clinical research has only shown that taking goji fruit polysaccharides with or without antidiabetes drugs modestly reduces postprandial glucose when compared with control, with no reports of hypoglycemia.

Likelihood Possible Evidence B
Monograph

Goji: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food. While they are popular for eye health, immune support, and general wellness, strong human evidence for most health claims is limited. Talk with your pharmacist or doctor before using concentrated goji supplements, especially if you take medications or are pregnant.

Goji
Scientific name
Lycium barbarum
Family
Solanaceae
Part used
Fruit (berries); root bark and leaves are also used in traditional medicine
Common forms
Dried berries, juice, capsules, powders, teas, extracts
People commonly use it for
  • General antioxidant support
  • Eye health
  • Immune support
  • Anti-aging and well-being
  • Blood sugar support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally safe as a food, but concentrated supplements have less safety data.

PregnancyInsufficient reliable information

Insufficient reliable information available. Some animal research shows that goji fruit may stimulate the uterus. However, this has not been reported...

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available. Some animal research shows that goji fruit may stimulate the uterus. However, this has not been reported...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Goji, also called wolfberry, is the small red-orange fruit of the Lycium barbarum shrub, a plant in the nightshade family. It grows mainly in China and other parts of Asia, where it has been used in food and traditional medicine for centuries.

The berries have a sweet, slightly tart taste and are usually sold dried, much like raisins. People eat them as a snack or add them to cereal, yogurt, soups, and tea. They are also made into juice, powders, and capsules. In traditional Chinese medicine, the root bark (called Di Gu Pi) and leaves are used too, though the berry is most popular today.

Goji is marketed as a "superfood" because it contains antioxidants, vitamins, minerals, fiber, and special plant sugars called polysaccharides. Some supplements are standardized for their polysaccharide content.

How it works

Goji berries contain several compounds that may explain their proposed effects. The most studied are Lycium barbarum polysaccharides (LBPs), which are plant sugars that may interact with the immune system and have antioxidant activity in laboratory studies.

The berries are also rich in carotenoids such as zeaxanthin and beta-carotene, which are pigments that help protect cells from oxidative stress and are concentrated in the eye. Goji also provides vitamin C, certain B vitamins, and minerals.

It is important to know that much of this research comes from test tube and animal studies. What happens in a lab dish does not always translate to real benefits in people.

Effectiveness

Does Goji work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 14 uses evaluated
14 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Goji, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 14 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Age-related macular degeneration (AMD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral goji berry reduces the risk of developing AMD.

Insufficient Reliable Evidence To Rate Cancer
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral goji for cancer, there is insufficient reliable information about the clinical effects of goji for this condition.

Insufficient Reliable Evidence To Rate Cardiovascular disease (CVD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral goji improves risk factors for CVD.

Insufficient Reliable Evidence To Rate Cognitive function
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral goji berry improves cognition in healthy young individuals.

Insufficient Reliable Evidence To Rate Cough
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral goji for cough, there is insufficient reliable information about the clinical effects of goji for this purpose.

Insufficient Reliable Evidence To Rate Depression
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral goji berry polysaccharide is beneficial for adolescents with subthreshold depression.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral goji berry polysaccharides improve glycemic control in patients with diabetes.

Insufficient Reliable Evidence To Rate Dry eye
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral goji for dry eye, there is insufficient reliable information about the clinical effects of goji for this purpose.

Insufficient Reliable Evidence To Rate Erectile dysfunction (ED)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral goji for ED, there is insufficient reliable information about the clinical effects of goji for this condition.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral goji root bark for hypertension, there is insufficient reliable information about the clinical effects of goji for this condition.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral goji berry juice improves weight loss.

Insufficient Reliable Evidence To Rate Quality of life
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that oral goji berry juice may modestly improve quality of life in healthy adults.

Insufficient Reliable Evidence To Rate Sunburn
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral goji extract can prevent sunburn.

Insufficient Reliable Evidence To Rate Tinnitus
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral goji for tinnitus, there is insufficient reliable information about the clinical effects of goji for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

For most healthy adults, eating goji berries as a food is considered safe. Concentrated supplements, juices, and extracts have less safety data, so use them more carefully.

Because goji is in the nightshade family, people with allergies to other foods or pollens may rarely react to it. Stop using it if you notice signs of an allergic reaction such as rash, itching, swelling, or trouble breathing.

Pregnancy: Avoid medicinal or supplement amounts of goji during pregnancy. There is not enough safety information, and traditional sources suggest it may affect the uterus.

Breastfeeding: There is not enough reliable information on goji supplements while breastfeeding, so it is best to be cautious and avoid concentrated products.

If you have diabetes, low blood pressure, or take prescription medicines, talk with your pharmacist or doctor before using goji supplements.

Side effects

Goji berries are usually well tolerated when eaten as a food. Some people may have mild digestive upset, such as gas or loose stools, especially with large amounts.

Allergic reactions are uncommon but possible, and can range from mild itching to more serious swelling or breathing problems. Stop use and seek medical care if these occur.

Concentrated juices and supplements may cause more noticeable effects, and very high intake could affect blood sugar or blood pressure in sensitive people. If you feel dizzy, shaky, or unwell after taking goji, stop and check with a healthcare professional.

Goji: Reported Adverse Effects

Documented safety reports on Goji from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Hepatitis Hepatic

Orally, consumption of goji berries has been associated with a single case report of autoimmune hepatitis. A case of acute hepatitis has also been reported in a female who consumed 2 ounces of a specific combination product (Euforia, Nuverus International) containing goji berry, pomegranate, curcumin, green tea, noni, acai berry, aloe vera, blueberry, resveratrol, mangosteen, and black seed, daily for one month. It is unclear whether the liver injury was caused by goji berry, other ingredients, or the combination.

  1. Franco, M., Monmany, J., Domingo, P., and Turbau, M. [Autoimmune hepatitis triggered by consumption of Goji berries]. Med.Clin.(Barc.) 9-22-2012;139(7):320-321.
  2. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012.
Pruritus Immunologic

Several cases of allergic reactions secondary to consumption of goji berries have been reported. Symptoms included facial angioedema with dyspnea, pharyngeal itching, itching in the mouth, ears, and axilla, labial angioedema, and perioral skin rash. Anaphylaxis has also been reported.

  1. Larramendi CH, García-Abujeta JL, Vicario S, García-Endrino A, López-Matas MA, García-Sedeño MD, et al. Goji berries (Lycium barbarum): Risk of allergic reactions in individuals with food allergy. J Investig Allergol Clin Immunol. 2012;22(5):345-50.
  2. Monzon, Ballarin S., Lopez-Matas, M. A., Saenz, Abad D., Perez-Cinto, N., and Carnes, J. Anaphylaxis associated with the ingestion of Goji berries (Lycium barbarum). J.Investig.Allergol.Clin.Immunol. 2011;21(7):567-570.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official or proven standard dose for goji. Amounts used in studies and products vary widely depending on whether you use dried berries, juice, or an extract.

The safest approach is to follow the directions on the product label and not exceed the recommended amount. Eating goji as a dried fruit is generally a small, food-level amount.

If you are considering goji supplements for a specific health reason, ask your pharmacist or doctor for guidance. They can help you choose a reputable product and make sure it fits with your other medicines and health conditions.

Pregnancy & Breastfeeding

Goji & Pregnancy

Insufficient reliable information

Insufficient reliable information available. Some animal research shows that goji fruit may stimulate the uterus. However, this has not been reported in humans. Until more is known, avoid using during pregnancy or lactation.

Goji & Breastfeeding

Insufficient reliable information

Insufficient reliable information available. Some animal research shows that goji fruit may stimulate the uterus. However, this has not been reported in humans. Until more is known, avoid using during pregnancy or lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 14 references that drive our Goji monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton, FL: CRC Press, LLC 1999.
  2. Lam AY, Elmer GW, Mohutsky MA. Possible interaction between warfarin and Lycium Barbarum. Ann Pharmacother 2001;35:1199-201.
  3. Leung H, Hung A, Hui AC, Chan TY. Warfarin overdose due to the possible effects of Lycium barbarum L. Food Chem Toxicol 2008;46:1860-2. PubMed
  4. Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (goji) juice, GoChi. J Altern Complement Med 2008;14:403-12.
  5. Rivera, C. A., Ferro, C. L., Bursua, A. J., and Gerber, B. S. Probable interaction between Lycium barbarum (goji) and warfarin. Pharmacotherapy 2012;32(3):e50-e53.
  6. Monzon, Ballarin S., Lopez-Matas, M. A., Saenz, Abad D., Perez-Cinto, N., and Carnes, J. Anaphylaxis associated with the ingestion of Goji berries (Lycium barbarum). J.Investig.Allergol.Clin.Immunol. 2011;21(7):567-570.
  7. Franco, M., Monmany, J., Domingo, P., and Turbau, M. [Autoimmune hepatitis triggered by consumption of Goji berries]. Med.Clin.(Barc.) 9-22-2012;139(7):320-321.
  8. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
  9. Larramendi CH, García-Abujeta JL, Vicario S, García-Endrino A, López-Matas MA, García-Sedeño MD, et al. Goji berries (Lycium barbarum): Risk of allergic reactions in individuals with food allergy. J Investig Allergol Clin Immunol. 2012;22(5):345-50.
  10. Cai H, Liu F, Zuo P, Huang G, Song Z, Wang T, et al. Practical application of antidiabetic efficacy of Lycium barbarum polysaccharide in patients with type 2 diabetes. Med Chem. 2015;11(4):383-90.
  11. Potterat O. Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med 2010;76(1):7-19.
  12. Guzmán CE, Guzmán-Moreno CG, Assad-Morell JL, Edgar Francisco Carrizales-Sepúlveda EF. Flecainide toxicity associated with the use of goji berries: a case report. Eur Heart J Case Rep. 2021;5(6):ytab204. PubMed
  13. Liu R, Tam TW, Mao J, et al. In vitro activity of Lycium barbarum (Goji) against major human phase I metabolism enzymes. Complement Integr Med. 2016;13(3):257-265.
  14. Zhang J, Tian L, Xie B. Bleeding due to a probable interaction between warfarin and Gouqizi (Lycium Barbarum L.). Toxicol Rep. 2015;2:1209-1212. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Goji

451 brands in our database make a supplement containing Goji.

Product directory

Supplement products with Goji

1,802 products in our database contain Goji. Open any to see its full ingredient list and every drug interaction we check.

100% Pure Goji Juice by EB Earth's Bounty Liquid 16 fl. Oz. · 473 mL View ingredients & interactions 100% Vegan Complete MultiVitamin by Purely Inspired Tablet Or Pill 90 Vegan Tablet(s) View ingredients & interactions 37 Strawberries by Purity Products Capsule 30 Capsule(s) View ingredients & interactions 8 Immortals by Ron Teeguarden's Dragon Herbs Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions 8 Immortals by Ron Teeguarden's Dragon Herbs Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions 8 Immortals by Ron Teeguarden's Dragon Herbs Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions 8 Immortals Drops by Ron Teeguarden's Dragon Herbs Liquid 60 Milliliter(s) · 2 Fluid Ounce(s) View ingredients & interactions 8Hr Sleep with Melatonin by 8 Hour Sleep Capsule 60 Capsule(s) View ingredients & interactions A50 by BPI Capsule 60 Capsule(s) View ingredients & interactions Absent Period by Merry Women Clinic Tablet Or Pill 150 Tablet(s) View ingredients & interactions Absolute Goji by California Academy of Health Liquid 32 Fluid Ounce(s) · 946 mL View ingredients & interactions Absolute Goji Powder by California Academy of Health Powder 4 oz. · 120 Gram(s) View ingredients & interactions Acai Advantage by Healthy Choice Naturals Capsule 60 Capsule(s) View ingredients & interactions Acai Complete by Buried Treasure Liquid Nutrients Liquid 32 fl. Oz. · 946 mL View ingredients & interactions Acai Super Berry Blend Antioxidant by L.A. Naturals Capsule 60 Liquid Veggie Cap(s) View ingredients & interactions Acai Supreme by Nature's Answer Liquid 16 fl. Oz. · 480 mL View ingredients & interactions Acai-Max by California Academy of Health Liquid 32 Ounce(s) · 946 mL View ingredients & interactions Acai, Mangosteen, Noni & Goji by LifeTIME Life's Basics Liquid 32 Fluid Ounce(s) · 946 Milliliter(s) View ingredients & interactions AcaiCleanse Natural 10 Day Acai Berry Detox by Garden Greens Tablet Or Pill 120 Tablet(s) View ingredients & interactions AcaiSplash Energizing Mixed Berry Drink by Garden Greens Liquid 32 fl. Oz. · 946 mL View ingredients & interactions Accell Meal Complete Superfruit by Systemic Formulas Powder 1000 Gram(s) View ingredients & interactions Acneed by Merry Clinic Capsule 150 Capsule(s) View ingredients & interactions Acneed by Merry Clinic Tablet Or Pill 180 Tablet(s) View ingredients & interactions ActiveEssentials by XYMOGEN Other (e.g. Tea Bag) 60 Packet(s) View ingredients & interactions
Pharmacist Counseling Corner

Goji: Common Questions

What is Goji used for, and does it work?
People use Goji for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Goji interact with prescription medications?
Yes. We list 1000 medications with a known interaction with Goji, including 2 rated major. Use the checker above to see how Goji interacts with a specific drug.
How are Goji interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Goji with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Goji interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What are Goji berries used for?
People commonly use Goji for general wellness, eye health, immune support, and as an antioxidant-rich food. However, strong human evidence for most of these uses is limited.
Are Goji berries safe to eat?
For most healthy adults, eating Goji berries as a food is considered safe. Concentrated supplements and juices have less safety data, so use them more cautiously and ask your pharmacist if unsure.
Can I take Goji while pregnant or breastfeeding?
It is best to avoid medicinal or supplement amounts during pregnancy and to be cautious while breastfeeding, since there is not enough reliable safety information.
Do Goji berries cause side effects?
Most people tolerate them well, but large amounts may cause mild digestive upset, and allergic reactions are possible though uncommon.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Goji

A rotating sample of real supplements in our database that list Goji — open any to see its full ingredients and every drug interaction we check.

See all 1,802 products with Goji →
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